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Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis
Joint Authors
Erlandsson, Malin C.
Talvik, Tiina
Lundell, Anna-Carin
Liivamägi, Hille
Uibo, Karin
Tarraste, Sirje
Rebane, Tiina
Pruunsild, Chris
Pullerits, Rille
Bokarewa, Maria
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Liver-derived insulin-like growth factor-1 (IGF-1) contributes bone formation.
Decreased IGF-1 levels are common in juvenile idiopathic arthritis (JIA), but whether IGF-1 is related to sex and differ during the pathogenic progress of JIA is unknown.
Objective.
The aim of this study was to examine IGF-1 levels in boys and girls with newly diagnosed JIA, with established JIA and in controls.
Methods.
The study group included 131 patients from the Estonian population-based prevalence JIA study.
Blood samples were obtained from 27 boys and 38 girls with early JIA (≤1 month from the diagnosis), 29 boys and 36 girls with established JIA (mean disease duration 18 months), and from 47 age- and sex-matched controls.
Results.
IGF-1 levels in boys were significantly decreased in early JIA compared to male controls, while IGF-1 levels in girls were comparable between JIA and controls.
In early JIA, IGF-1 levels were 12-fold lower in boys relative to girls.
In controls, IGF-1 levels correlated with both age and height, while these correlations were lost in boys with early JIA.
Conclusion.
We report a sex-dependent deficiency in serum IGF-1 in boys with early JIA, which argues for sex-related differences in biological mechanisms involved in the disease pathogenesis.
American Psychological Association (APA)
Lundell, Anna-Carin& Erlandsson, Malin C.& Bokarewa, Maria& Liivamägi, Hille& Uibo, Karin& Tarraste, Sirje…[et al.]. 2018. Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192252
Modern Language Association (MLA)
Lundell, Anna-Carin…[et al.]. Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192252
American Medical Association (AMA)
Lundell, Anna-Carin& Erlandsson, Malin C.& Bokarewa, Maria& Liivamägi, Hille& Uibo, Karin& Tarraste, Sirje…[et al.]. Low Serum IGF-1 in Boys with Recent Onset of Juvenile Idiopathic Arthritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192252
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192252