miR-6869-5p Inhibits Glioma Cell Proliferation and Invasion via Targeting PGK1

Abstract EN

Accumulating studies have suggested the dysregulated microRNAs (miRNAs) play important roles in brain tumors, including glioma.

miR-6869-5p has been documented to be aberrantly expressed in diverse cancers.

However, the precise role of miR-6869-5p in glioma remains poorly understood.

This study is aimed at evaluating its modifying effects on glioma.

Significantly decreased expression of miR-6869-5p was found in glioma tissues and cells.

Negative association was documented between miR-6869-5p and PGK1 in glioma cells, and PGK1 was demonstrated to be a targeted gene of this miRNA by luciferase reporter assay.

miR-6869-5p regulated glioma cell proliferation and invasion via targeting PGK1.

In addition, the survival analysis had suggested that low miR-6869-5p expression predicted poor prognosis of glioma patients.

This study has suggested that miR-6869-5p is a useful tumor suppressor and prognostic marker in glioma.