Complement System as a Target for Therapies to Control Liver RegenerationDamage in Acute Liver Failure Induced by Viral Hepatitis
Joint Authors
Pacheco-Moreira, Lúcio F.
Melgaço, Juliana Gil
Pinto, Marcelo Alves
Veloso, Carlos Eduardo
Vitral, Claudia Lamarca
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The complement system plays an important role in innate immunity inducing liver diseases as well as signaling immune cell activation in local inflammation regulating immunomodulatory effects such as liver damage and/or liver regeneration.
Our aim is to evaluate the role of complement components in acute liver failure (ALF) caused by viral hepatitis, involving virus-induced ALF in human subjects using peripheral blood, samples of liver tissues, and ex vivo assays.
Our findings displayed low levels of C3a in plasma samples with high frequency of C3a, C5a, and C5b/9 deposition in liver parenchyma.
Meanwhile, laboratory assays using HepG2 (hepatocyte cell line) showed susceptibility to plasma samples from ALF patients impairing in vitro cell proliferation and an increase in apoptotic events submitting plasma samples to heat inactivation.
In summary, our data suggest that the complement system may be involved in liver dysfunction in viral-induced acute liver failure cases using ex vivo assays.
In extension to our findings, we provide insights into future studies using animal models for viral-induced ALF, as well as other associated soluble components, which need further investigation.
American Psychological Association (APA)
Melgaço, Juliana Gil& Veloso, Carlos Eduardo& Pacheco-Moreira, Lúcio F.& Vitral, Claudia Lamarca& Pinto, Marcelo Alves. 2018. Complement System as a Target for Therapies to Control Liver RegenerationDamage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192258
Modern Language Association (MLA)
Melgaço, Juliana Gil…[et al.]. Complement System as a Target for Therapies to Control Liver RegenerationDamage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192258
American Medical Association (AMA)
Melgaço, Juliana Gil& Veloso, Carlos Eduardo& Pacheco-Moreira, Lúcio F.& Vitral, Claudia Lamarca& Pinto, Marcelo Alves. Complement System as a Target for Therapies to Control Liver RegenerationDamage in Acute Liver Failure Induced by Viral Hepatitis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192258
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192258