The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance
Joint Authors
Zhao, Bingjie
Chang, Lu
Fu, Haiying
Sun, Guangyu
Yang, Wei
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Autoimmune regulator (AIRE), whose gene mutation is considered to be a causative factor of autoimmune polyglandular syndrome type 1 (APS1), is an important transcriptional regulator.
Studies on the role of AIRE in the central immune system have demonstrated that AIRE can eliminate autoreactive T cells by regulating the expression of a series of tissue specific antigens promiscuously in medullary thymic epithelial cells (mTECs) and induce regulatory T cell (Treg) production to maintain central immune tolerance.
However, the related research of AIRE in peripheral tolerance is few.
In order to understand the current research progress on AIRE in peripheral tolerance, this review mainly focuses on the expression and distribution of AIRE in peripheral tissues and organs, and the role of AIRE in peripheral immune tolerance such as regulating Toll-like receptor (TLR) expression and the maturation status of antigen presenting cells (APCs), inducing T cell tolerance and differentiation.
This review will show us that AIRE also plays an indispensable role in the periphery.
American Psychological Association (APA)
Zhao, Bingjie& Chang, Lu& Fu, Haiying& Sun, Guangyu& Yang, Wei. 2018. The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192264
Modern Language Association (MLA)
Zhao, Bingjie…[et al.]. The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1192264
American Medical Association (AMA)
Zhao, Bingjie& Chang, Lu& Fu, Haiying& Sun, Guangyu& Yang, Wei. The Role of Autoimmune Regulator (AIRE) in Peripheral Tolerance. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192264
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192264