The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis

Joint Authors

Lech, Maciej
Honarpisheh, Mohsen
Köhler, Paulina
von Rauchhaupt, Ekaterina

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-15, 15 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-05-08

Country of Publication

Egypt

No. of Pages

15

Main Subjects

Biology

Abstract EN

Noncoding RNAs (ncRNAs), including microRNAs (miRNAs), represent a family of RNA molecules that do not translate into protein.

Nevertheless, they have the ability to regulate gene expression and play an essential role in immune cell differentiation and function.

MicroRNAs were found to be differentially expressed in various tissues, and changes in their expression have been associated with several pathological processes.

Yet, their roles in systemic lupus erythematosus (SLE) and lupus nephritis (LN) remain to be elucidated.

Both SLE and LN are characterized by a complex dysfunction of the innate and adaptive immunity.

Recently, significant findings have been made in understanding SLE through the use of genetic variant identification and expression pattern analysis and mouse models, as well as epigenetic analyses.

Abnormalities in immune cell responses, cytokine and chemokine production, cell activation, and apoptosis have been linked to a unique expression pattern of a number of miRNAs that have been implicated in the immune pathogenesis of this autoimmune disease.

The recent evidence that significantly increased the understanding of the pathogenesis of SLE drives a renewed interest in efficient therapy targets.

This review aims at providing an overview of the current state of research on the expression and role of miRNAs in the immune pathogenesis of SLE and LN.

American Psychological Association (APA)

Honarpisheh, Mohsen& Köhler, Paulina& von Rauchhaupt, Ekaterina& Lech, Maciej. 2018. The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192274

Modern Language Association (MLA)

Honarpisheh, Mohsen…[et al.]. The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis. Journal of Immunology Research No. 2018 (2018), pp.1-15.
https://search.emarefa.net/detail/BIM-1192274

American Medical Association (AMA)

Honarpisheh, Mohsen& Köhler, Paulina& von Rauchhaupt, Ekaterina& Lech, Maciej. The Involvement of MicroRNAs in Modulation of Innate and Adaptive Immunity in Systemic Lupus Erythematosus and Lupus Nephritis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-15.
https://search.emarefa.net/detail/BIM-1192274

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192274