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Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats
Joint Authors
Nampoothiri, Madhavan
Misra, Chandrasekhar
Jitta, Srinivasa Reddy
Daram, Prasanthi
Gourishetti, Karthik
Polu, Picheswara Rao
Shah, Abhishek
Shreedhara, C. S.
Lobo, Richard
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Terminalia tomentosa bark belongs to the family Combretaceae.
The plant bark is astringent and useful in the treatment of ulcers, vata, fractures, hemorrhages, bronchitis, and diarrhea.
Phytochemical investigation of T.
tomentosa bark confirms the presence of flavonoids, polyphenols, and tannins.
The plant has not been investigated for its anti-inflammatory and antiarthritic activity.
The present study was undertaken to explore its possible anti-inflammatory and antiarthritic activity.
Anti-inflammatory activity of alcoholic and aqueous extracts of the bark was assessed by in vivo methods.
In vivo antiarthritic potential of the extracts was evaluated by Complete Freund’s Adjuvant (CFA) induced arthritis in Wistar rats.
Our findings showed that the alcoholic and aqueous extracts exhibited anti-inflammatory activity at 500 mg/kg oral dose in carrageenan-induced hind paw edema and carrageenan-induced air pouch inflammation models.
We also found alcoholic as well as aqueous extracts of the bark restored the altered blood and serum parameters caused by the Complete Freund’s Adjuvant-induced arthritis in Wistar rats.
This study shows that the T.
tomentosa bark extracts possess anti-inflammatory activity and have pronounced effects on adjuvant arthritis also.
Future studies are necessary to provide deeper insight into the exact mechanism of the action of anti-inflammatory and antiarthritic activity of T.
tomentosa.
American Psychological Association (APA)
Jitta, Srinivasa Reddy& Daram, Prasanthi& Gourishetti, Karthik& Misra, Chandrasekhar& Polu, Picheswara Rao& Shah, Abhishek…[et al.]. 2019. Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats. Journal of Toxicology،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192285
Modern Language Association (MLA)
Jitta, Srinivasa Reddy…[et al.]. Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats. Journal of Toxicology No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1192285
American Medical Association (AMA)
Jitta, Srinivasa Reddy& Daram, Prasanthi& Gourishetti, Karthik& Misra, Chandrasekhar& Polu, Picheswara Rao& Shah, Abhishek…[et al.]. Terminalia tomentosa Bark Ameliorates Inflammation and Arthritis in Carrageenan Induced Inflammatory Model and Freund’s Adjuvant-Induced Arthritis Model in Rats. Journal of Toxicology. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192285
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192285