Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy
Joint Authors
Lunardi, C.
Antonio, Puccetti
Giuseppe, Argentino
Patuzzo, Giuseppe
Pelosi, Andrea
Fiore, Piera Filomena
Moretta, Francesca
Dolcino, Marzia
Tinazzi, E.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-24
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Behçet disease (BD) is a chronic inflammatory multisystem disease characterized by oral and genital ulcers, uveitis, and skin lesions.
Disease etiopathogenesis is still unclear.
We aim to elucidate some aspects of BD pathogenesis and to identify specific gene signatures in peripheral blood cells (PBCs) of patients with active disease using novel gene expression and network analysis.
179 genes were modulated in 10 PBCs of BD patients when compared to 10 healthy donors.
Among differentially expressed genes the top enriched gene function was immune response, characterized by upregulation of Th17-related genes and type I interferon- (IFN-) inducible genes.
Th17 polarization was confirmed by FACS analysis.
The transcriptome identified gene classes (vascular damage, blood coagulation, and inflammation) involved in the pathogenesis of the typical features of BD.
Following network analysis, the resulting interactome showed 5 highly connected regions (clusters) enriched in T and B cell activation pathways and 2 clusters enriched in type I IFN, JAK/STAT, and TLR signaling pathways, all implicated in autoimmune diseases.
We report here the first combined analysis of the transcriptome and interactome in PBCs of BD patients in the active stage of disease.
This approach generates useful insights in disease pathogenesis and suggests an autoimmune component in the origin of BD.
American Psychological Association (APA)
Antonio, Puccetti& Fiore, Piera Filomena& Pelosi, Andrea& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. 2018. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
Modern Language Association (MLA)
Antonio, Puccetti…[et al.]. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
American Medical Association (AMA)
Antonio, Puccetti& Fiore, Piera Filomena& Pelosi, Andrea& Tinazzi, E.& Patuzzo, Giuseppe& Giuseppe, Argentino…[et al.]. Gene Expression Profiling in Behcet’s Disease Indicates an Autoimmune Component in the Pathogenesis of the Disease and Opens New Avenues for Targeted Therapy. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192292
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192292