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Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens
Joint Authors
Chen, Shu-Jen
Zheng, Lei
Pan, Ren-You
Chung, Wen-Hung
Chu, Mu-Tzu
Chen, Hua-Chien
Hung, Shuen-Iu
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Recently, increasing data show that immunotherapy could be a powerful weapon against cancers.
Comparing to the traditional surgery, chemotherapy or radiotherapy, immunotherapy more specifically targets cancer cells, giving rise to the opportunities to the patients to have higher response rates and better quality of life and even to cure the disease.
Cancer vaccines could be designed to target tumor-associated antigens (TAAs), cancer germline antigens, virus-associated antigens, or tumor-specific antigens (TSAs), which are also called neoantigens.
The cancer vaccines could be cell-based (e.g., dendritic cell vaccine provenge (sipuleucel-T) targeting prostatic acid phosphatase for metastatic prostate cancer), peptide/protein-based, or gene- (DNA/RNA) based, with the different kinds of adjuvants.
Neoantigens are tumor-specific and could be presented by MHC molecules and recognized by T lymphocytes, serving the ideal immune targets to increase the therapeutic specificity and decrease the risk of nonspecific autoimmunity.
By targeting the shared antigens and private epitopes, the cancer vaccine has potential to treat the disease.
Accordingly, personalized neoantigen-based immunotherapies are emerging.
In this article, we review the literature and evidence of the advantage and application of cancer vaccine.
We summarize the recent clinical trials of neoantigen cancer vaccines which were designed according to the patients’ personal mutanome.
With the rapid development of personalized immunotherapy, it is believed that tumors could be efficiently controlled and become curable in the new era of precision medicine.
American Psychological Association (APA)
Pan, Ren-You& Chung, Wen-Hung& Chu, Mu-Tzu& Chen, Shu-Jen& Chen, Hua-Chien& Zheng, Lei…[et al.]. 2018. Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192302
Modern Language Association (MLA)
Pan, Ren-You…[et al.]. Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192302
American Medical Association (AMA)
Pan, Ren-You& Chung, Wen-Hung& Chu, Mu-Tzu& Chen, Shu-Jen& Chen, Hua-Chien& Zheng, Lei…[et al.]. Recent Development and Clinical Application of Cancer Vaccine: Targeting Neoantigens. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192302