The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya

Joint Authors

Murithi, Wilfred
Verver, Suzanne
Kaguthi, G.
Nduba, V.

Source

Journal of Tropical Medicine

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-07-03

Country of Publication

Egypt

No. of Pages

10

Main Subjects

Medicine

Abstract EN

There is inadequate understanding of the epidemiology of Non-Tuberculous Mycobacteria (NTM) among infants in high tuberculosis burden countries.

The objective of this study was to document the incidence and diversity of NTM disease or colonisation in sputum specimens from infants with presumptive TB, the risk factors, and clinical characteristics, in a high TB and HIV burden setting in Western Kenya.

A cohort of 2900 newborns was followed for 1–2 years to assess TB incidence.

TB investigations included collection of induced sputa and gastric aspirates for culture and speciation by HAIN®, Tuberculin Skin Testing (TST), HIV testing, and chest radiography.

The American Thoracic Society Criteria (ATS) were applied to identify NTM disease.

Among 927 (32% of 2900) with presumptive TB, 742 (80%) were investigated.

NTM were isolated from 19/742 (2.6%) infants.

M.

fortuitum was most frequently speciated (32%).

Total person-time was 3330 years.

NTM incidence was 5.7/1,000 person-years, 95% CI (3.5, 8.7).

Infants diagnosed with TB were more likely to have NTM isolation (odds ratio 11.5; 95% CI 3.25, 41.0).

None of the infants with NTM isolated met the criteria for NTM disease.

The incidence of NTM isolation was comparable to similar studies in Africa.

NTM isolation did not meet ATS criteria for disease and could represent colonisation.

TB disease appears to be structural lung disease predisposing to NTM colonisation.

American Psychological Association (APA)

Kaguthi, G.& Nduba, V.& Murithi, Wilfred& Verver, Suzanne. 2019. The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya. Journal of Tropical Medicine،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192305

Modern Language Association (MLA)

Kaguthi, G.…[et al.]. The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya. Journal of Tropical Medicine No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1192305

American Medical Association (AMA)

Kaguthi, G.& Nduba, V.& Murithi, Wilfred& Verver, Suzanne. The Incidence of Non-Tuberculous Mycobacteria in Infants in Kenya. Journal of Tropical Medicine. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192305

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192305