Circulating Monocytes, Tissue Macrophages, and Malaria
Joint Authors
Ozarslan, Nida
Robinson, Joshua F.
Gaw, Stephanie L.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-10-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Malaria is a significant cause of global morbidity and mortality.
The Plasmodium parasite has a complex life cycle with mosquito, liver, and blood stages.
The blood stages can preferentially affect organs such as the brain and placenta.
In each of these stages and organs, the parasite will encounter monocytes and tissue-specific macrophages—key cell types in the innate immune response.
Interactions between the Plasmodium parasite and monocytes/macrophages lead to several changes at both cellular and molecular levels, such as cytokine release and receptor expression.
In this review, we summarize current knowledge on the relationship between malaria and blood intervillous monocytes and tissue-specific macrophages of the liver (Kupffer cells), central nervous system (microglia), and placenta (maternal intervillous monocytes and fetal Hofbauer cells).
We describe their potential roles in modulating outcomes from infection and areas for future investigation.
American Psychological Association (APA)
Ozarslan, Nida& Robinson, Joshua F.& Gaw, Stephanie L.. 2019. Circulating Monocytes, Tissue Macrophages, and Malaria. Journal of Tropical Medicine،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192322
Modern Language Association (MLA)
Ozarslan, Nida…[et al.]. Circulating Monocytes, Tissue Macrophages, and Malaria. Journal of Tropical Medicine No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192322
American Medical Association (AMA)
Ozarslan, Nida& Robinson, Joshua F.& Gaw, Stephanie L.. Circulating Monocytes, Tissue Macrophages, and Malaria. Journal of Tropical Medicine. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192322