Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease
Joint Authors
Gelders, Géraldine
Baekelandt, Veerle
Van der Perren, Anke
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-16
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society.
Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases.
Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death.
Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD.
Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration.
Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research.
Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression.
In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.
American Psychological Association (APA)
Gelders, Géraldine& Baekelandt, Veerle& Van der Perren, Anke. 2018. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192399
Modern Language Association (MLA)
Gelders, Géraldine…[et al.]. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192399
American Medical Association (AMA)
Gelders, Géraldine& Baekelandt, Veerle& Van der Perren, Anke. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192399
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192399