Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

Joint Authors

Gelders, Géraldine
Baekelandt, Veerle
Van der Perren, Anke

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-16

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Biology

Abstract EN

Neurodegenerative diseases such as Parkinson’s disease (PD) and Alzheimer’s disease (AD) impose a pressing burden on our developed and consequently aging society.

Misfolded protein aggregates are a critical aspect of several neurodegenerative diseases.

Nevertheless, several questions remain unanswered regarding the role of misfolded protein aggregates and the cause of neuronal cell death.

Recently, it has been postulated that neuroinflammatory processes might play a crucial role in the pathogenesis of PD.

Numerous postmortem, brain imaging, epidemiological, and animal studies have documented the involvement of the innate and adaptive immunity in neurodegeneration.

Whether these inflammatory processes are directly involved in the etiology of PD or represent secondary consequences of nigrostriatal pathway injury is the subject of intensive research.

Immune alterations in response to extracellular α-synuclein may play a critical role in modulating Parkinson’s disease progression.

In this review, we address the current concept of neuroinflammation and its involvement in PD-associated neurodegeneration.

American Psychological Association (APA)

Gelders, Géraldine& Baekelandt, Veerle& Van der Perren, Anke. 2018. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192399

Modern Language Association (MLA)

Gelders, Géraldine…[et al.]. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1192399

American Medical Association (AMA)

Gelders, Géraldine& Baekelandt, Veerle& Van der Perren, Anke. Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1192399

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192399