The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers
Joint Authors
Gidron, Y.
De Couck, M.
Schallier, D.
Van Laethem, J. L.
Maréchal, R.
De Greve, J.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-08
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
The vagus nerve may slow tumor progression because it inhibits inflammation.
This study examined the relationship between a new vagal neuroimmunomodulation (NIM) index and survival in fatal cancers.
Method.
We retroactively derived markers of vagal nerve activity indexed by heart rate variability (HRV), specifically the root mean square of successive differences (RMSSD), from patients’ electrocardiograms near diagnosis.
The NIM index was the ratio of RMSSD to C-reactive protein levels (RMSSD/CRP).
Sample 1 included 202 Belgian patients with advanced pancreatic cancer (PC), while sample 2 included 71 Belgian patients with non-small cell lung cancer (NSCLC).
In both samples, we examined the overall survival, while in sample 2, we additionally examined the survival time in deceased patients.
Results.
In PC patients, in a multivariate Cox regression controlling for confounders, the NIM index had a protective relative risk (RR) of 0.68 and 95% confidence interval (95% CI) of 0.51–0.92.
In NSCLC patients, the NIM index also had a protective RR of 0.53 and 95% CI of 0.32–0.88.
Finally, in NSCLC, patients with a higher NIM index survived more days (475.2) than those with lower NIM (285.1) (p<0.05).
Conclusions.
The NIM index, reflecting vagal modulation of inflammation, may be a new independent prognostic biomarker in fatal cancers.
American Psychological Association (APA)
Gidron, Y.& De Couck, M.& Schallier, D.& De Greve, J.& Van Laethem, J. L.& Maréchal, R.. 2018. The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1192413
Modern Language Association (MLA)
Gidron, Y.…[et al.]. The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers. Journal of Immunology Research No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1192413
American Medical Association (AMA)
Gidron, Y.& De Couck, M.& Schallier, D.& De Greve, J.& Van Laethem, J. L.& Maréchal, R.. The Relationship between a New Biomarker of Vagal Neuroimmunomodulation and Survival in Two Fatal Cancers. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1192413
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192413