The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases
Joint Authors
Cardoso, Andréia M.
Bagatini, Margarete D.
Santos, Alessandra
Carvalho, Fabiano
Reschke, Cristina R.
Mânica, Aline
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-21, 21 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
21
Main Subjects
Abstract EN
Evidences show that purinergic signaling is involved in processes associated with health and disease, including noncommunicable, neurological, and degenerative diseases.
These diseases strike from children to elderly and are generally characterized by progressive deterioration of cells, eventually leading to tissue or organ degeneration.
These pathological conditions can be associated with disturbance in the signaling mediated by nucleotides and nucleosides of adenine, in expression or activity of extracellular ectonucleotidases and in activation of P2X and P2Y receptors.
Among the best known of these diseases are atherosclerosis, hypertension, cancer, epilepsy, Alzheimer’s disease (AD), Parkinson’s disease (PD), and multiple sclerosis (MS).
The currently available treatments present limited effectiveness and are mostly palliative.
This review aims to present the role of purinergic signaling highlighting the ectonucleotidases E-NTPDase, E-NPP, E-5′-nucleotidase, and adenosine deaminase in noncommunicable, neurological, and degenerative diseases associated with the cardiovascular and central nervous systems and cancer.
In conclusion, changes in the activity of ectonucleotidases were verified in all reviewed diseases.
Although the role of ectonucleotidases still remains to be further investigated, evidences reviewed here can contribute to a better understanding of the molecular mechanisms of highly complex diseases, which majorly impact on patients’ quality of life.
American Psychological Association (APA)
Bagatini, Margarete D.& Santos, Alessandra& Cardoso, Andréia M.& Mânica, Aline& Reschke, Cristina R.& Carvalho, Fabiano. 2018. The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1192417
Modern Language Association (MLA)
Bagatini, Margarete D.…[et al.]. The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases. Journal of Immunology Research No. 2018 (2018), pp.1-21.
https://search.emarefa.net/detail/BIM-1192417
American Medical Association (AMA)
Bagatini, Margarete D.& Santos, Alessandra& Cardoso, Andréia M.& Mânica, Aline& Reschke, Cristina R.& Carvalho, Fabiano. The Impact of Purinergic System Enzymes on Noncommunicable, Neurological, and Degenerative Diseases. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-21.
https://search.emarefa.net/detail/BIM-1192417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192417