Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients
Joint Authors
Elsayed, Naglaa M.
Ali, Hala M.
ElRawi, Hoda A.
Ghanem, Nashwa S.
Rashed, Laila A.
Mansour, Mai M.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Purpose.
The current study aimed at assessing vitamin D level and vitamin D receptor polymorphism in hypothyroid Egyptian patients and its effect on hypothyroidism and thyroid morphology, also to find a causal relation between vitamin D and hypothyroidism.
Methods.
This case-control study was conducted on 35 hypothyroid patients and 35 matched unrelated healthy controls.
Total serum 25-hydroxyvitamin D3 and thyroid antibodies were measured using a human ELISA kit.
Genotyping was performed by using real-time PCR.
HOMA-IR was also calculated (fasting insulin in mIU/L × fasting glucose in mg/dL/405).
All subjects were assessed for thyroid morphology by thyroid ultrasonography.
Results.
Vitamin D level was lower in hypothyroid patients than in control subjects.
Vitamin D was also inversely related to TSH, HOMA-IR, and levels of anti-TG and anti-TPO.
VDR polymorphism (Fok1 and Apa1) had no relation to TSH or vitamin D levels in both patients and control groups.
Low vitamin D levels were associated with increased thyroid vascularity and nodularity; furthermore, vitamin D was inversely proportional to thyroid gland volume.
Correlation of HOMA-IR with the levels of both anti-TG and anti-TPO in the 70 subjects proved that HOMA-IR was positively correlated to both antibodies.
Conclusion.
This study confirmed the association of vitamin D deficiency with hypothyroidism, thyroid autoimmunity, increased volume, nodularity, and vascularity of thyroid gland in hypothyroid patients as well as increased HOMA-IR.
It proved the association between HOMA-IR and thyroid autoimmunity.
The study proved no association between VDR polymorphisms (Fok1 and Apa1) with either vitamin D levels or TSH levels.
American Psychological Association (APA)
ElRawi, Hoda A.& Ghanem, Nashwa S.& Elsayed, Naglaa M.& Ali, Hala M.& Rashed, Laila A.& Mansour, Mai M.. 2019. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. Journal of Thyroid Research،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192425
Modern Language Association (MLA)
ElRawi, Hoda A.…[et al.]. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. Journal of Thyroid Research No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1192425
American Medical Association (AMA)
ElRawi, Hoda A.& Ghanem, Nashwa S.& Elsayed, Naglaa M.& Ali, Hala M.& Rashed, Laila A.& Mansour, Mai M.. Study of Vitamin D Level and Vitamin D Receptor Polymorphism in Hypothyroid Egyptian Patients. Journal of Thyroid Research. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192425
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192425