Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients
Joint Authors
Hoshino, Yoshihiko
Niki, Mamiko
Niki, Makoto
Kaneko, Yukihiro
Matsumoto, Sohkichi
Okumura, Masao
Yoshiyama, Takashi
Miyamoto, Yuji
Oinuma, Ken-ichi
Sasaki, Yuka
Ogata, Hideo
Goto, Hajime
Kudoh, Shoji
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
A novel tuberculosis vaccine to replace BCG has long been desired.
However, recent vaccine trials focused on cell-mediated immunity have failed to produce promising results.
It is worth noting that most commercially available successful vaccines rely on humoral immunity.
To establish a basic understanding of humoral immunity against tuberculosis, we analyzed and evaluated longitudinal levels and avidity of immunoglobulin to various tuberculosis antigens compared with bacterial and clinical parameters during treatment.
We found that levels of IgG antibodies against HrpA and HBHA prior to treatment exhibited a positive correlation with bacterial burden.
Analysis of changes in CRP during treatment revealed an association with high levels of specific IgG and IgA antibodies against mycobacterial antigens.
Levels of CRP prior to treatment were negatively associated with IgG avidity to CFP-10 and MDP1 and IgA avidity to HrpA, while IgA avidity to MDP1 and Acr exhibited a negative correlation with CRP levels after 60 days of treatment.
These results may provide insight for the development of a novel tuberculosis (TB) vaccine candidate to induce protective humoral immunity against tuberculosis.
American Psychological Association (APA)
Niki, Mamiko& Yoshiyama, Takashi& Miyamoto, Yuji& Okumura, Masao& Niki, Makoto& Oinuma, Ken-ichi…[et al.]. 2018. Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192426
Modern Language Association (MLA)
Niki, Mamiko…[et al.]. Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192426
American Medical Association (AMA)
Niki, Mamiko& Yoshiyama, Takashi& Miyamoto, Yuji& Okumura, Masao& Niki, Makoto& Oinuma, Ken-ichi…[et al.]. Longitudinal Evaluation of Humoral Immunity and Bacterial and Clinical Parameters Reveals That Antigen-Specific Antibodies Suppress Inflammatory Responses in Active Tuberculosis Patients. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192426
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192426