Recent Advances in Drug-Induced Hypersensitivity SyndromeDrug Reaction with Eosinophilia and Systemic Symptoms
Author
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-18
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Drug-induced hypersensitivity syndrome (DIHS), also termed as drug reaction with eosinophilia and systemic symptoms (DRESS), is a multiorgan systemic reaction characterized by a close relationship with the reactivation of herpes virus.
Published data has demonstrated that among patients with DIHS/DRESS, 75–95% have leukocytosis, 18.2–90% show atypical lymphocytes, 52–95% have eosinophilia, and 75–100% have hepatic abnormalities.
Histologically, eosinophils were observed less frequently than we expected (20%).
The mainstay of DIHS/DRESS treatment is a moderate dose of systemic corticosteroids, followed by gradual dose reduction.
In this review, we will emphasize that elevations in the levels of several cytokines/chemokines, including tumor necrosis factor- (TNF-) α and the thymus and activation-regulated chemokine (TARC/CCL17), during the early stage of disease, are good markers allowing the early recognition of HHV-6 reactivation.
TNF-α and TARC levels also reflect therapeutic responses and may be useful markers of the DIHS disease process.
Recently, the pathogenic mechanism of T-cell activation triggered by human leukocyte antigen- (HLA-) restricted presentation of a drug or metabolites was elucidated.
Additionally, we recently reported that dapsone would fit within the unique subpocket of the antigen-recognition site of HLA-B∗13:01.
Further studies will render it possible to choose better strategies for DIHS prevention and therapy.
American Psychological Association (APA)
Watanabe, Hideaki. 2018. Recent Advances in Drug-Induced Hypersensitivity SyndromeDrug Reaction with Eosinophilia and Systemic Symptoms. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192486
Modern Language Association (MLA)
Watanabe, Hideaki. Recent Advances in Drug-Induced Hypersensitivity SyndromeDrug Reaction with Eosinophilia and Systemic Symptoms. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192486
American Medical Association (AMA)
Watanabe, Hideaki. Recent Advances in Drug-Induced Hypersensitivity SyndromeDrug Reaction with Eosinophilia and Systemic Symptoms. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192486
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192486