The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response

Joint Authors

Zhu, Liqian
Jones, Clinton
Zhang, Gaiping

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-02-08

Country of Publication

Egypt

No. of Pages

9

Main Subjects

Biology

Abstract EN

Macrophages are crucial members of the mononuclear phagocyte system essential to protect the host from invading pathogens and are central to the inflammatory response with their ability to acquire specialized phenotypes of inflammatory (M1) and anti-inflammatory (M2) and to produce a pool of inflammatory mediators.

Equipped with a broad range of receptors, such as Toll-like receptor 4 (TLR4), CD14, and Fc gamma receptors (FcγRs), macrophages can efficiently recognize and phagocytize invading pathogens and secrete cytokines by triggering various secondary signaling pathways.

Phospholipase C (PLC) is a family of enzymes that hydrolyze phospholipids, the most significant of which is phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2].

Cleavage at the internal phosphate ester generates two second messengers, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), both of which mediate in diverse cellular functions including the inflammatory response.

Recent studies have shown that some PLC isoforms are involved in multiple stages in TLR4-, CD14-, and FcγRs-mediated activation of nuclear factor kappa B (NF-κB), mitogen-activated protein kinase (MAPK), and interferon regulatory factors (IRFs), all of which are associated with the regulation of the inflammatory response.

Therefore, secondary signaling by PLC is implicated in the pathogenesis of numerous inflammatory diseases.

This review provides an overview of our current knowledge on how PLC signaling regulates the macrophage-mediated inflammatory response.

American Psychological Association (APA)

Zhu, Liqian& Jones, Clinton& Zhang, Gaiping. 2018. The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192533

Modern Language Association (MLA)

Zhu, Liqian…[et al.]. The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response. Journal of Immunology Research No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1192533

American Medical Association (AMA)

Zhu, Liqian& Jones, Clinton& Zhang, Gaiping. The Role of Phospholipase C Signaling in Macrophage-Mediated Inflammatory Response. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1192533

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192533