The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1
Joint Authors
Li, Yuanyuan
Zhu, Leqing
Bin, Lianghua
He, Longzhen
Wang, Baocheng
Li, Peiling
Zou, Feiyan
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The innate immune response is the first line defense against viral infections.
Novel genes involved in this system are continuing to emerge.
SLC15A3, a proton-coupled histidine and di-tripeptide transporter that was previously found in lysosomes, has been reported to inhibit chikungunya viral replication in host cells.
In this study, we found that SLC15A3 was significantly induced by DNA virus herpes simplex virus-1(HSV-1) in monocytes from human peripheral blood mononuclear cells.
Aside from monocytes, it can also be induced by HSV-1 in 293T, HeLa cells, and HaCaT cells.
Overexpression of SLC15A3 in 293T cells inhibits HSV-1 replication and enhances type I and type III interferon (IFN) responses, while silencing SLC15A3 leads to enhanced HSV-1 replication with reduced IFN production.
Moreover, we found that SLC15A3 interacted with MAVS and STING and potentiated MAVS- and STING-mediated IFN production.
These results demonstrate that SLC15A3 participates in anti-HSV-1 innate immune responses by regulating MAVS- and STING-mediated signaling pathways.
American Psychological Association (APA)
He, Longzhen& Wang, Baocheng& Li, Yuanyuan& Zhu, Leqing& Li, Peiling& Zou, Feiyan…[et al.]. 2018. The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192536
Modern Language Association (MLA)
He, Longzhen…[et al.]. The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192536
American Medical Association (AMA)
He, Longzhen& Wang, Baocheng& Li, Yuanyuan& Zhu, Leqing& Li, Peiling& Zou, Feiyan…[et al.]. The Solute Carrier Transporter SLC15A3 Participates in Antiviral Innate Immune Responses against Herpes Simplex Virus-1. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192536
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192536