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NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness
Joint Authors
Fellig, Y.
Oded, Abramsky
Mizrachi, Tehila
Brill, Livnat
Rabie, Malcolm
Nevo, Yoram
Zur, Mayan
Karussis, Dimitrios
Brenner, Talma
Vaknin-Dembinsky, Adi
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-22
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Neuromyelitis optica (NMO) and myasthenia gravis (MG) are autoimmune diseases mediated by autoantibodies against either aquaporin 4 (AQP4) or acetylcholine receptor (AChR), respectively.
Recently, we and others have reported an increased prevalence of NMO in patients with MG.
To verify whether coexisting autoimmune disease may exacerbate experimental autoimmune MG, we tested whether active immunization with AQP4 peptides or passive transfer of NMO-Ig can affect the severity of EAMG.
Injection of either AQP4 peptide or NMO-Ig to EAMG or to naive mice caused increased fatigability and aggravation of EAMG symptoms as expressed by augmented muscle weakness (but not paralysis), decremental response to repetitive nerve stimulation, increased neuromuscular jitter, and aberration of immune responses.
Thus, our study shows increased disease severity in EAMG mice following immunization with the NMO autoantigen AQP4 or by NMO-Ig, mediated by augmented inflammatory response.
This can explain exacerbation or increased susceptibility of patients with one autoimmune disease to develop additional autoimmune syndrome.
American Psychological Association (APA)
Mizrachi, Tehila& Brill, Livnat& Rabie, Malcolm& Nevo, Yoram& Fellig, Y.& Zur, Mayan…[et al.]. 2018. NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192607
Modern Language Association (MLA)
Mizrachi, Tehila…[et al.]. NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192607
American Medical Association (AMA)
Mizrachi, Tehila& Brill, Livnat& Rabie, Malcolm& Nevo, Yoram& Fellig, Y.& Zur, Mayan…[et al.]. NMO-IgG and AQP4 Peptide Can Induce Aggravation of EAMG and Immune-Mediated Muscle Weakness. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192607