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Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis
Joint Authors
Ogawa, Youichi
Kinoshita, Manao
Shimada, Shinji
Kawamura, Tatsuyoshi
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the skin, the epidermis is continuously exposed to various kinds of external substances and stimuli.
Therefore, epidermal barriers are crucial for providing protection, safeguarding health, and regulating water balance by maintaining skin homeostasis.
Disruption of the epidermal barrier allows external substances and stimuli to invade or stimulate the epidermal cells, leading to the elicitation of skin inflammation.
The major components of the epidermal barrier are the stratum corneum (SC) and tight junctions (TJs).
The presence of zinc in the epidermis promotes epidermal homeostasis; hence, this study reviewed the role of zinc in the formation and function of the SC and TJs.
Langerhans cells (LCs) are one of the antigen-presenting cells found in the epidermis.
They form TJs with adjacent keratinocytes (KCs), capture external antigens, and induce antigen-specific immune reactions.
Thus, the function of zinc in LCs was examined in this review.
We also summarized the general knowledge of zinc and zinc transporters in the epidermis with updated findings.
American Psychological Association (APA)
Ogawa, Youichi& Kinoshita, Manao& Shimada, Shinji& Kawamura, Tatsuyoshi. 2018. Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192611
Modern Language Association (MLA)
Ogawa, Youichi…[et al.]. Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192611
American Medical Association (AMA)
Ogawa, Youichi& Kinoshita, Manao& Shimada, Shinji& Kawamura, Tatsuyoshi. Zinc in Keratinocytes and Langerhans Cells: Relevance to the Epidermal Homeostasis. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192611
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192611