Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice
Joint Authors
Sun, Yu
Han, Shuhong
Wang, Kexin
Song, Feng
Xu, Kai
Liu, Zhi
Li, Fangna
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Diabetes mellitus (DM) patients experience memory and cognitive deficits.
The mechanisms underlying this dysfunction in the brain of DM patients are not fully understood, and therefore, no optimized therapeutic strategy has been established so far.
The aim of the present study was to assess whether irisin was able to improve memory and cognitive performance in a streptozotocin-induced diabetic mouse model.
A diabetic mouse model was established and behavioral tests were performed.
We also set up primary cultures for mechanism studies.
Western blots and EMSA were used for molecular studies.
Significant impairment of cognition and memory was observed in these DM mice, which could be effectively prevented by irisin cotreatment.
We also found upregulated levels of GFAP protein, reduced synaptic protein expression, and increased levels of interleukin-1β (IL-1β) and interleukin-6 (IL-6) in the brains; however, irisin significantly attenuated these cellular responses.
Meanwhile, our results demonstrated that irisin inhibited the activation of P38, STAT3, and NFκB proteins of DM mice.
Furthermore, our results suggested that irisin might regulate the function of P38, STAT3, and NFκB in hippocampal tissues of DM mice.
Collectively, irisin inhibited neuroinflammation in STZ-induced DM mice by inhibiting cytokine release and improving their cognitive function.
Our findings revealed the mechanism of irisin’s anti-inflammatory effect in the CNS.
American Psychological Association (APA)
Wang, Kexin& Song, Feng& Xu, Kai& Liu, Zhi& Han, Shuhong& Li, Fangna…[et al.]. 2019. Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192612
Modern Language Association (MLA)
Wang, Kexin…[et al.]. Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192612
American Medical Association (AMA)
Wang, Kexin& Song, Feng& Xu, Kai& Liu, Zhi& Han, Shuhong& Li, Fangna…[et al.]. Irisin Attenuates Neuroinflammation and Prevents the Memory and Cognitive Deterioration in Streptozotocin-Induced Diabetic Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192612
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192612