Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1
Joint Authors
Fan, HuiZhen
Jiang, Chunyan
Zhong, Baoyuan
Sheng, Jianwen
Chen, Ting
Chen, Qingqing
Li, Jingtao
Zhao, Hongchuan
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Matrine may be protective against colorectal cancer (CRC), but how it may work is unclear.
Thus, we explored the underlying mechanisms of matrine in CRC.
Matrine-related proteins and CRC-related genes and therapeutic targets of matrine in CRC were predicted using a network pharmacology approach.
Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism.
Expression of predicted serum targets were verified in a 1,2-dimethylhydrazine dihydrochloride-induced CRC model rats that were treated with matrine (ip) for 18 weeks.
Data show that matrine suppressed CRC growth and decreased previously elevated expression of IL-6, TNF-α, p53, and HMGB1.
Matrine may have had a therapeutic effect on CRC via inhibition of HMGB1 signaling, and this occurred through downregulation of IL-6, TNF-α, and HMGB1.
American Psychological Association (APA)
Fan, HuiZhen& Jiang, Chunyan& Zhong, Baoyuan& Sheng, Jianwen& Chen, Ting& Chen, Qingqing…[et al.]. 2018. Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192618
Modern Language Association (MLA)
Fan, HuiZhen…[et al.]. Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1192618
American Medical Association (AMA)
Fan, HuiZhen& Jiang, Chunyan& Zhong, Baoyuan& Sheng, Jianwen& Chen, Ting& Chen, Qingqing…[et al.]. Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192618