NLRP3: A Novel Mediator in Cardiovascular Disease
Joint Authors
Chen, Yanfang
Jiang, Jie
Zhao, Mingyi
Zhou, Wenyi
Chen, Chunyuan
Liu, Lin
Wu, Zhixiang
Chen, Zhiheng
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cardiovascular disease is a major cause of death worldwide.
Inflammasome infiltration has been identified to play a central role in the pathological progression of certain cardiovascular diseases, such as vascular damage spanning atherosclerosis, aneurysm, or arteritis; ischemic heart disease; and other nonischemic heart diseases including diabetic cardiomyopathy, chronic heart failure, and hypertension- or virus-induced cardiac dysfunction.
The NLRP3 inflammasome, a key participant in the innate immune response, requires both priming and activation signals for the initiation of inflammation.
Piling evidence has revealed that the NLRP3 inflammasome could exert an inflammatory effect by inducing the secretion of proinflammatory cytokines (i.e., IL-1β, IL-18) or could cause pyroptosis, a novel programmed cell death process, in a caspase-1-dependent manner.
The importance of the NLRP3 inflammasome in cardiac disease has been broadly investigated.
In this review, we present the current knowledge regarding the function of NLRP in vascular disease, ischemic heart disease, and nonischemic heart disease and discuss the potential therapeutic options targeting the NLRP3 inflammasome.
American Psychological Association (APA)
Zhou, Wenyi& Chen, Chunyuan& Chen, Zhiheng& Liu, Lin& Jiang, Jie& Wu, Zhixiang…[et al.]. 2018. NLRP3: A Novel Mediator in Cardiovascular Disease. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192639
Modern Language Association (MLA)
Zhou, Wenyi…[et al.]. NLRP3: A Novel Mediator in Cardiovascular Disease. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1192639
American Medical Association (AMA)
Zhou, Wenyi& Chen, Chunyuan& Chen, Zhiheng& Liu, Lin& Jiang, Jie& Wu, Zhixiang…[et al.]. NLRP3: A Novel Mediator in Cardiovascular Disease. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192639
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192639