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Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis
Joint Authors
Rachid, Milene
Cramer, Allysson
de Lima Oliveira, Bruno Cabral
Leite, Paulo Gaio
Rodrigues, David Henrique
Brant, Fatima
Esper, Lisia
Pimentel, Pollyana Maria Oliveira
Rezende, Rafael Machado
Teixeira, Antonio Lucio
Faria, Ana Maria Caetano
Machado, Fabiana Simão
Teixeira, Mauro Martins
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-23
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Multiple sclerosis (MS) is an inflammatory disease of the central nervous system (CNS).
Experimental Autoimmune Encephalomyelitis (EAE) is the most widely used animal model for the study of MS.
The Suppressor of Cytokine Signaling (SOCS) 2 protein plays a critical role in regulating the immune responses.
The role of SOCS2 during EAE has not been explored.
EAE was induced in WT and SOCS2-/- mice using myelin oligodendrocyte glycoprotein (MOG35-55) peptide.
Brain and spinal cord were examined during the peak (day 14) and recovery phase (day 28) of the disease.
SOCS2 was upregulated in the brain of WT mice at the peak and recovery phase of EAE.
The development of the acute phase was slower in onset in SOCS2-/- mice and was associated with reduced number of Th1 (CD3+CD4+IFN-γ+) cells in the spinal cord and brain.
However, while in WT mice, maximal clinical EAE score was followed by a progressive recovery; the SOCS2-/- mice were unable to recover from locomotor impairment that occurred during the acute phase.
There was a prolonged inflammatory response (increased Th1 and decreased Th2 and T regulatory cells) in the late phase of EAE in the CNS of SOCS2-/- mice.
Transplantation of bone marrow cells from SOCS2-/- into irradiated WT mice resulted in higher lethality at the early phase of EAE.
Altogether, these results suggest that SOCS2 plays a dual role in the immune response during EAE.
It is necessary for damage during the acute phase damage but plays a beneficial role in the recovery stage of the disease.
American Psychological Association (APA)
Cramer, Allysson& de Lima Oliveira, Bruno Cabral& Leite, Paulo Gaio& Rodrigues, David Henrique& Brant, Fatima& Esper, Lisia…[et al.]. 2019. Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192645
Modern Language Association (MLA)
Cramer, Allysson…[et al.]. Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1192645
American Medical Association (AMA)
Cramer, Allysson& de Lima Oliveira, Bruno Cabral& Leite, Paulo Gaio& Rodrigues, David Henrique& Brant, Fatima& Esper, Lisia…[et al.]. Role of SOCS2 in the Regulation of Immune Response and Development of the Experimental Autoimmune Encephalomyelitis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192645
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192645