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Evaluation of the Treatment Effect of Aloe vera Fermentation in Burn Injury Healing Using a Rat Model
Joint Authors
Chen, Tingtao
Hai, Zhiwen
Ren, Yimeng
Hu, Jiawen
Wang, Huan
Qin, Qi
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-27
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Burn injury is a growing medical problem associated with public health, and few effective agents are available for treatment of this disease.
In the present study, a burn injury rat model was developed and the accelerated effect of Aloe vera fermentation on burn injury healing was evaluated.
Our results indicated that Aloe vera fermentation could markedly reduce the DPPH (56.12%), O2⋅− (93.5%), ⋅OH (76.12%), Fe2+ chelation (82%), and oxygen-reduction activity (0.28 μg/ml) and significantly inhibited the growth of pathogens S.
typhimurium ATCC 13311 (inhibition zone diameter: 14 mm), S.
enteritidis ATCC13076 (IZD: 13 mm), S.
flexneri ATCC 12022 (IZD: 18 mm), E.
coli 44102 (IZD: 10 mm), L.
monocytogenes ATCC 19111 (IZD: 18 mm), S.
dysenteriae 301 (IZD: 20 mm), S.
aureus COWAN1 (IZD: 19 mm), and P.
acnes ATCC 11827 (IZD: 25 mm) in vitro.
The in vivo results indicated that Aloe vera fermentation produced more eosinophils and fibroblasts and less vessel proliferation compared with the model group on the 14th day, which had greatly accelerated burn injury healing via shedding of the scab and promoting hair growth.
ELISA results indicated that Aloe vera fermentation had significantly reduced the production of proinflammatory factors TNF-α and IL-1β (p<0.05) and greatly enhanced the yield of anti-inflammatory factor IL-4 in animal serum (p<0.05).
In addition, the high-throughput sequencing results indicated that Aloe vera fermentation obviously increased the percentage of Firmicutes (65.86% vs.
49.76%), while reducing the number of Bacteroidetes (27.60% vs.
45.15%) compared with the M group at the phylum level.
At the genus level, Aloe vera fermentation increased the probiotic bacteria Lactobacillus (3.13% vs.
2.09%) and reduced the pathogens Prevotella (10.60% vs.18.24%) and Blautia (2.91% vs.
16.41%) compared with the M group.
Therefore, we concluded that the use of Aloe vera fermentation significantly accelerates burn injury healing via reduction of the severity of inflammation and through modification of gut microbiota.
American Psychological Association (APA)
Hai, Zhiwen& Ren, Yimeng& Hu, Jiawen& Wang, Huan& Qin, Qi& Chen, Tingtao. 2019. Evaluation of the Treatment Effect of Aloe vera Fermentation in Burn Injury Healing Using a Rat Model. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192665
Modern Language Association (MLA)
Hai, Zhiwen…[et al.]. Evaluation of the Treatment Effect of Aloe vera Fermentation in Burn Injury Healing Using a Rat Model. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192665
American Medical Association (AMA)
Hai, Zhiwen& Ren, Yimeng& Hu, Jiawen& Wang, Huan& Qin, Qi& Chen, Tingtao. Evaluation of the Treatment Effect of Aloe vera Fermentation in Burn Injury Healing Using a Rat Model. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192665
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192665