Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis
Joint Authors
Huang, Ying
Xu, Lijun
Zhu, Biao
Xu, Yufan
Peng, Xiuming
Chen, Yaokai
Guo, Yongzheng
Zhao, Yizhou
Yang, Zongxing
Tao, Ran
Xu, Yan
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Serum cytokines/chemokines play important roles in cryptococcal meningitis, but it is unclear whether cytokines/chemokines in cerebrospinal fluid (CSF) contribute to high intracranial pressure (HICP) in HIV-associated cryptococcal meningitis (HCM).
Methods.
CSF cytokines/chemokines were assayed in 17 HIV-uninfected patients, 26 HIV-infected patients without CNS infection, and 39 HCM patients at admission.
Principal component analysis and correlation and logistic regression analyses were used to assess the relationships between these parameters.
Results.
The CSF Th1, Th2, and macrophage cytokines showed an obvious increase in HCM patients as compared to the HIV-uninfected patients and HIV-infected patients without CNS infection.
CSF IL-6, GM-CSF, and IL-8 were positively correlated with CSF fungal burden.
Serum CD4 count, CSF Th1 cytokines (TNF-α, TNF-β, IL-12, IL-1β, and INF-α2), and Th2 cytokines (IL-5 and IL-6) were closely related to cryptococcal meningitis.
Furthermore, both Th1 cytokines (TNF-α, TNF-β, INF-γ, and IL-12) and Th2 cytokines (IL-4 and IL-10) contribute to HICP.
Conclusion.
Overall, the present findings indicated that both pro- and anti-inflammatory cytokines of Th1, Th2, and macrophage origin contributed to the development of HCM.
Specifically, the chemokine and cytokine cascade caused by skewing of the Th1-Th2 balance and reduced CD4 count were found to be important contributors to HICP.
Summary.
Our research suggested that chemokine and cytokine cascade caused by skewing of the Th1-Th2 balance in HIV-infected patients played more important role than Cryptococcus numbers and size in CSF on the development of high intracranial pressure in HIV-associated cryptococcal meningitis, providing a new understanding of mechanisms of HCM.
American Psychological Association (APA)
Xu, Lijun& Guo, Yongzheng& Zhao, Yizhou& Xu, Yufan& Peng, Xiuming& Yang, Zongxing…[et al.]. 2019. Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192668
Modern Language Association (MLA)
Xu, Lijun…[et al.]. Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192668
American Medical Association (AMA)
Xu, Lijun& Guo, Yongzheng& Zhao, Yizhou& Xu, Yufan& Peng, Xiuming& Yang, Zongxing…[et al.]. Chemokine and Cytokine Cascade Caused by Skewing of the Th1-Th2 Balance Is Associated with High Intracranial Pressure in HIV-Associated Cryptococcal Meningitis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192668