Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis
Joint Authors
Poskerova, Hana
Kavrikova, Denisa
Lucanova, Svetlana
Izakovicova Holla, Lydie
Borilova Linhartova, Petra
Fassmann, Antonin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Periodontitis, an inflammatory disease caused by subgingival Gram-negative (G-) bacteria, is linked with loss of the connective tissue and destruction of the alveolar bone.
In the regulation of inflammatory response, chemokine receptor 2 (CXCR2), a specific receptor for interleukin-8 and neutrophil chemoattractant, plays an important role.
The first aim of this study was to investigate the CXCR2 gene variability in chronic periodontitis (CP) patients and healthy nonperiodontitis controls in the Czech population.
The second aim was to find a relation between CXCR2 gene variants and the presence of periodontal bacteria.
A total of 500 unrelated subjects participated in this case-control study.
329 CP patients and 171 healthy nonperiodontitis controls were analyzed using polymerase chain reaction techniques for three single-nucleotide polymorphisms (SNPs): +785C/T (rs2230054), +1208T/C (rs1126579), and +1440A/G (rs1126580).
A DNA microarray detection kit was used for the investigation of the subgingival bacterial colonization, in a subgroup of CP subjects (N=162).
No significant differences in allele, genotype, haplotype, or haplogenotype frequencies of CXCR2 gene variants between patients with CP and healthy controls (P>0.05) were determined.
Nevertheless, Aggregatibacter actinomycetemcomitans was detected more frequently in men positive for the C allele of the CXCR2 +785C/T polymorphism (61.8% vs.
41.1%, P<0.05; OR=2.31, 95% CI=1.03-5.20) and for the T allele of the CXCR2 +1208C/T variant (61.8% vs.
38.9%, P<0.05; OR=2.54, 95% CI=1.13-5.71).
In contrast, no statistically significant associations of CXCR2 variants with seven selected periodontal bacteria were found in women.
Although none of the investigated SNPs in the CXCR2 gene was associated with CP, the CXCR2 gene variants can be associated with subgingival colonization of G- bacteria in men with CP in the Czech population.
American Psychological Association (APA)
Kavrikova, Denisa& Borilova Linhartova, Petra& Lucanova, Svetlana& Poskerova, Hana& Fassmann, Antonin& Izakovicova Holla, Lydie. 2019. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192672
Modern Language Association (MLA)
Kavrikova, Denisa…[et al.]. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. Mediators of Inflammation No. 2019 (2019), pp.1-8.
https://search.emarefa.net/detail/BIM-1192672
American Medical Association (AMA)
Kavrikova, Denisa& Borilova Linhartova, Petra& Lucanova, Svetlana& Poskerova, Hana& Fassmann, Antonin& Izakovicova Holla, Lydie. Chemokine Receptor 2 (CXCR2) Gene Variants and Their Association with Periodontal Bacteria in Patients with Chronic Periodontitis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-8.
https://search.emarefa.net/detail/BIM-1192672
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192672