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Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies
Joint Authors
Bobosha, Kidist
Alelign, Tilahun
Petros, Beyene
Howe, Rawleigh
Tadesse, Yewondwossen
Ahmed, Momina M.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-05
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Kidney transplantation remains the treatment of choice for end-stage renal failure.
When the immune system of the recipient recognizes the transplanted kidney as a foreign object, graft rejection occurs.
As part of the host immune defense mechanism, human leukocyte antigen (HLA) is a major challenge for graft rejection in transplantation therapy.
The impact of HLA mismatches between the donor and the potential recipient prolongs the time for renal transplantation therapy, tethered to dialysis, latter reduces graft survival, and increases mortality.
The formation of pretransplant alloantibodies against HLA class I and II molecules can be sensitized through exposures to blood transfusions, prior transplants, and pregnancy.
These preformed HLA antibodies are associated with rejection in kidney transplantation.
On the other hand, the development of de novo antibodies may increase the risk for acute and chronic rejections.
Allograft rejection results from a complex interplay involving both the innate and the adaptive immune systems.
Thus, further insights into the mechanisms of tissue rejection and the risk of HLA sensitization is crucial in developing new therapies that may blunt the immune system against transplanted organs.
Therefore, the purpose of this review is to highlight facts about HLA and its sensitization, various mechanisms of allograft rejection, the current immunosuppressive approaches, and the directions for future therapy.
American Psychological Association (APA)
Alelign, Tilahun& Ahmed, Momina M.& Bobosha, Kidist& Tadesse, Yewondwossen& Howe, Rawleigh& Petros, Beyene. 2018. Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192680
Modern Language Association (MLA)
Alelign, Tilahun…[et al.]. Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies. Journal of Immunology Research No. 2018 (2018), pp.1-18.
https://search.emarefa.net/detail/BIM-1192680
American Medical Association (AMA)
Alelign, Tilahun& Ahmed, Momina M.& Bobosha, Kidist& Tadesse, Yewondwossen& Howe, Rawleigh& Petros, Beyene. Kidney Transplantation: The Challenge of Human Leukocyte Antigen and Its Therapeutic Strategies. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-18.
https://search.emarefa.net/detail/BIM-1192680
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192680