Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis
Joint Authors
Monaco, Maria Ludovica
Polito, Rita
Iacotucci, Paola
Carnovale, Vincenzo
Comegna, Marika
Gelzo, Monica
Corso, Gaetano
Daniele, Aurora
Castaldo, Giuseppe
Nigro, Ersilia
Zarrilli, Federica
Elce, Ausilia
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cystic fibrosis (CF) is a genetic disease characterized by progressive decline of lung function and chronic airway inflammation.
Adipose tissue, through adiponectin and leptin, exerts several effects on energy metabolism and inflammatory processes.
This study evaluated the levels of adiponectin and leptin in adult healthy subjects, in patients with CF and their correlation with long-term physical activity.
CF patients were divided into two groups (sedentary versus active) based on their regular physical activity over 3 years.
Anthropometric and serum biochemical profiles of CF patients and controls were evaluated and compared.
Total serum adiponectin and leptin levels were measured by ELISA; adiponectin oligomeric profiles were analysed by western blot.
Adiponectin levels were significantly higher while leptin levels were lower in patients with CF than in healthy controls.
Furthermore, adiponectin was significantly lower in active compared to sedentary CF (p=0.047), while leptin was slightly increased in active compared to sedentary CF.
In addition, C-reactive protein levels were significantly lower in active than in sedentary CF patients (p=0.048).
Interestingly, only in the active group adiponectin levels were inversely correlated with forced expiratory volume (FEV) 1% decrease/year and FEV1% decrease.
Moreover, adiponectin levels negatively correlated with lipid profiles.
Our findings indicated that regular, long-term physical activity in CF improves respiratory function, metabolism, and inflammation status.
These improvements in patients’ conditions are associated with immunometabolic processes involving adiponectin, leptin, and C-reactive protein.
Therefore, we propose that both adipokines may be a useful biomarker in the evaluation of metabolic and inflammatory status in patients with CF.
American Psychological Association (APA)
Polito, Rita& Nigro, Ersilia& Elce, Ausilia& Monaco, Maria Ludovica& Iacotucci, Paola& Carnovale, Vincenzo…[et al.]. 2019. Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192682
Modern Language Association (MLA)
Polito, Rita…[et al.]. Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis. Mediators of Inflammation No. 2019 (2019), pp.1-7.
https://search.emarefa.net/detail/BIM-1192682
American Medical Association (AMA)
Polito, Rita& Nigro, Ersilia& Elce, Ausilia& Monaco, Maria Ludovica& Iacotucci, Paola& Carnovale, Vincenzo…[et al.]. Adiponectin Expression Is Modulated by Long-Term Physical Activity in Adult Patients Affected by Cystic Fibrosis. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-7.
https://search.emarefa.net/detail/BIM-1192682
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192682