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miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells
Joint Authors
Chen, Fangjie
Liu, Hong
Wu, Jingjing
Zhao, Yanyan
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thioredoxin reductase (TrxR), an antioxidant enzyme dependent on nicotinamide adenine dinucleotide phosphate, plays a vital role in defense against oxidative stress.
However, the role of microRNAs targeting TrxR under oxidative stress has not yet been determined.
In this study, we tested the involvement of miRNA-mediated posttranscriptional regulation in H2O2-induced TrxR1 expression in endothelial cells.
Dual luciferase assay combined with expression analysis confirmed that miR-125a suppressed TrxR1 expression by targeting its 3′-UTR.
Furthermore, H2O2 induced TrxR1 expression partly through downregulation of miR-125a.
These findings indicate that miRNA-mediated posttranscriptional mechanism is involved in H2O2-induced TrxR1 expression in endothelial cells, suggesting an important role of miRNAs in the response to oxidative stress.
American Psychological Association (APA)
Chen, Fangjie& Liu, Hong& Wu, Jingjing& Zhao, Yanyan. 2018. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192697
Modern Language Association (MLA)
Chen, Fangjie…[et al.]. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192697
American Medical Association (AMA)
Chen, Fangjie& Liu, Hong& Wu, Jingjing& Zhao, Yanyan. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192697