miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells

Joint Authors

Chen, Fangjie
Liu, Hong
Wu, Jingjing
Zhao, Yanyan

Source

Journal of Immunology Research

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-08-26

Country of Publication

Egypt

No. of Pages

7

Main Subjects

Biology

Abstract EN

Thioredoxin reductase (TrxR), an antioxidant enzyme dependent on nicotinamide adenine dinucleotide phosphate, plays a vital role in defense against oxidative stress.

However, the role of microRNAs targeting TrxR under oxidative stress has not yet been determined.

In this study, we tested the involvement of miRNA-mediated posttranscriptional regulation in H2O2-induced TrxR1 expression in endothelial cells.

Dual luciferase assay combined with expression analysis confirmed that miR-125a suppressed TrxR1 expression by targeting its 3′-UTR.

Furthermore, H2O2 induced TrxR1 expression partly through downregulation of miR-125a.

These findings indicate that miRNA-mediated posttranscriptional mechanism is involved in H2O2-induced TrxR1 expression in endothelial cells, suggesting an important role of miRNAs in the response to oxidative stress.

American Psychological Association (APA)

Chen, Fangjie& Liu, Hong& Wu, Jingjing& Zhao, Yanyan. 2018. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192697

Modern Language Association (MLA)

Chen, Fangjie…[et al.]. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1192697

American Medical Association (AMA)

Chen, Fangjie& Liu, Hong& Wu, Jingjing& Zhao, Yanyan. miR-125a Suppresses TrxR1 Expression and Is Involved in H2O2-Induced Oxidative Stress in Endothelial Cells. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1192697

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192697