Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients
Joint Authors
Pereira, Sanívia Aparecida de Lima
Helmo, Fernanda Rodrigues
da Silva, Emerson Abdulmassih Wood
da Silva, Natalia Maria Jacom Wood
Rodrigues, Rafael Rocha
Ribeiro, Betânia Maria
Mendonça, Mônica Sawan
Rodrigues, Virmondes
Adad, Sheila Jorge
Rodrigues, Denise Bertulucci Rocha
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-20
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Helicobacter pylori (H.
pylori) is a highly prevalent bacterium in our environment, directly involved in various upper digestive tract diseases, such as gastritis, peptic ulcer, and gastric cancer.
Several molecules activating the immune system have been reported to be involved in containing H.
pylori infection.
This study is aimed at analyzing the mRNA expression of the cytokines IFN-γ, IL-17, IL-10, TGF-β, IL-6, IL-22, IL-23, and IL-33; transcription factors T-bet, RORC, and FOXP3; enzymes ARG1, ARG2, and NOS2; and neuropeptides VIP and TAC and their respective receptors VIPR1 and TACR1 in the stomach lining of patients with severe digestive disorders.
One hundred and twenty six patients have been evaluated, presenting with symptoms in the upper digestive tract, with the clinical indication for an Upper Digestive Endoscopy exam.
Two fragments of the mucosa of the gastric body and antrum have been collected for anatomopathological examination and to analyze the expression of enzymes, cytokines, and transcription factors using qPCR.
Expression of the ARG1 gene was seen as significantly higher in the group of patients with chronic inactive gastritis than in the control group.
Expression of the TGF-β gene and its FOXP3 transcription factor was significantly higher in the group of chronic inactive gastritis patients than in the control.
Expression of IFN-γ, IL-17, IL-10, and TGF-β and the transcription factors, T-bet and RORC, in the presence or absence of H.
pylori showed no significant difference.
However, the expression of FOXP3 was significantly lower in H.
pylori-positive patients than that in H.
pylori-negative patients.
ARG1 and Treg profile appeared to be modulating the inflammatory process, protecting patients from the tissue lesions with chronic inactive gastritis.
Furthermore, we suggest that IL-33 may be a crucial mediator of the immune response against an infection, after gastric mucosal damage.
American Psychological Association (APA)
da Silva, Emerson Abdulmassih Wood& da Silva, Natalia Maria Jacom Wood& Rodrigues, Rafael Rocha& Adad, Sheila Jorge& Pereira, Sanívia Aparecida de Lima& Ribeiro, Betânia Maria…[et al.]. 2019. Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192720
Modern Language Association (MLA)
da Silva, Emerson Abdulmassih Wood…[et al.]. Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients. Mediators of Inflammation No. 2019 (2019), pp.1-11.
https://search.emarefa.net/detail/BIM-1192720
American Medical Association (AMA)
da Silva, Emerson Abdulmassih Wood& da Silva, Natalia Maria Jacom Wood& Rodrigues, Rafael Rocha& Adad, Sheila Jorge& Pereira, Sanívia Aparecida de Lima& Ribeiro, Betânia Maria…[et al.]. Arginase-1 and Treg Profile Appear to Modulate Inflammatory Process in Patients with Chronic Gastritis: IL-33 May Be the Alarm Cytokine in H. pylori-Positive Patients. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-11.
https://search.emarefa.net/detail/BIM-1192720
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192720