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Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease
Joint Authors
Ning, Longui
Zhang, Fenming
Xu, Guoqiang
Lou, Xinhe
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-01-21
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Nuclear receptors (NRs) are ligand-dependent transcription factors that regulate the transcription of target genes.
Previous epidemiological and genetic studies have documented the association of NRs with the risk of inflammatory bowel disease (IBD).
Although the mechanisms of action of NRs in IBD have not been fully established, accumulating evidence has demonstrated that NRs play complicated roles in regulating intestinal immunity, mucosal barriers, and intestinal flora.
As one of the first-line medications for the treatment of IBD, 5-aminosalicylic acid (5-ASA) activates peroxisome proliferator-activated receptor gamma (PPARγ) to attenuate colitis.
The protective roles of rifaximin and rifampicin partly depend on promoting pregnane X receptor (PXR) expression.
The aims of this review are to discuss the roles of several important NRs, such as PPARγ, PXR, vitamin D receptor (VDR), farnesoid X receptor (FXR), and RAR-related orphan receptor gammat (RORγt), in the pathogenesis of IBD and management strategies based on targeting these receptors.
American Psychological Association (APA)
Ning, Longui& Lou, Xinhe& Zhang, Fenming& Xu, Guoqiang. 2019. Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192723
Modern Language Association (MLA)
Ning, Longui…[et al.]. Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192723
American Medical Association (AMA)
Ning, Longui& Lou, Xinhe& Zhang, Fenming& Xu, Guoqiang. Nuclear Receptors in the Pathogenesis and Management of Inflammatory Bowel Disease. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192723
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192723