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Aberrant Peripheral Immune Function in a Good Syndrome Patient
Joint Authors
Xie, Weiping
Shang, Wenwen
Wang, Fang
Zhang, Jiexin
Chen, Xian
Jin, Shu-xian
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Good’s syndrome (GS) is often accompanied by recurrent respiratory infections and chronic diarrhea.
The main purpose was to evaluate the peripheral immune status of a GS patient after thymoma resection.
Twenty healthy volunteers were recruited as healthy controls (HCs).
Flow cytometry was applied to determine the proportions of circuiting CD4+ T cells, CD8+ T cells, γδT cells, and regulatory T (Treg) cells in our GS patient.
We also examined the proliferation capability of ex vivo CD4+ T cells and detected the levels of cytokines interferon- (IFN-) γ and interleukin-17A secreted by ex vivo immune cells from this GS patient.
Compared with healthy control subjects, this GS patient had fewer B cells, an inverted ratio of CD4+/CD8+ cells, and more Treg cells in his peripheral blood.
Additionally, the patient’s Vδ2 T cell levels were significantly decreased despite having a normal percentage of γδT cells.
Ex vivo peripheral CD4+ T cells from the patient showed insufficient proliferation and division potential as well as excessive expression of PD-1.
Moreover, IFN-γ was predominantly derived from CD8+ T cells in this GS patient, rather than from CD4+ T cells and γδT cells.
This GS patient had impaired T and B cell immunological alternations and cytokine disruptions after thymectomy.
Detailed research should focus on therapies that can adjust the immune status in such patients for a better outcome.
American Psychological Association (APA)
Chen, Xian& Zhang, Jiexin& Shang, Wenwen& Xie, Weiping& Jin, Shu-xian& Wang, Fang. 2018. Aberrant Peripheral Immune Function in a Good Syndrome Patient. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192738
Modern Language Association (MLA)
Chen, Xian…[et al.]. Aberrant Peripheral Immune Function in a Good Syndrome Patient. Journal of Immunology Research No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1192738
American Medical Association (AMA)
Chen, Xian& Zhang, Jiexin& Shang, Wenwen& Xie, Weiping& Jin, Shu-xian& Wang, Fang. Aberrant Peripheral Immune Function in a Good Syndrome Patient. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1192738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192738