TRIF Regulates BICmiR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response
Joint Authors
Ye, Jinshan
Guo, Ruiwei
Yang, Lixia
Wu, Yaxi
Liang, Xing
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Toll/IL-1R-domain-containing adaptor-inducing IFN-β (TRIF) is an important adaptor for TLR3- and TLR4-mediated inflammatory signaling pathways.
Recent studies have shown that TRIF plays a key role in vessel inflammation and atherosclerosis; however, the precise mechanisms are unclear.
We investigated the mechanisms of the TRIF-regulated inflammatory response in RAW264.7 macrophages under oxidized low-density lipoprotein (ox-LDL) stimulation.
Our data show that ox-LDL induces TRIF, miR-155, and BIC expression, activates the ERK1/2 and SOCS1-STAT3-NF-κB signaling pathways, and elevates the levels of IL-6 and TNF-α in RAW264.7 cells.
Knockdown of TRIF using TRIF siRNA suppressed BIC, miR-155, IL-6, and TNF-α expression and inhibited the ERK1/2 and SOCS1-STAT3-NF-κB signaling pathways.
Inhibition of ERK1/2 signaling also suppressed BIC and miR-155 expression.
These findings suggest that TRIF plays an important role in regulating the ox-LDL-induced macrophage inflammatory response and that TRIF modulates the expression of BIC/miR-155 and the downstream SOCS1-STAT3-NF-κB signaling pathway via ERK1/2.
Therefore, TRIF might be a novel therapeutic target for atherosclerosis.
American Psychological Association (APA)
Wu, Yaxi& Ye, Jinshan& Guo, Ruiwei& Liang, Xing& Yang, Lixia. 2018. TRIF Regulates BICmiR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192745
Modern Language Association (MLA)
Wu, Yaxi…[et al.]. TRIF Regulates BICmiR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response. Journal of Immunology Research No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1192745
American Medical Association (AMA)
Wu, Yaxi& Ye, Jinshan& Guo, Ruiwei& Liang, Xing& Yang, Lixia. TRIF Regulates BICmiR-155 via the ERK Signaling Pathway to Control the ox-LDL-Induced Macrophage Inflammatory Response. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1192745
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192745