Roles of Inflammasomes in Inflammatory Kidney Diseases
Joint Authors
Yu, Xueqing
Fan, Jinjin
Zheng, Nuoyan
Xie, Kaifeng
Wang, Liqin
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-21
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The immune system has a central role in eliminating detrimental factors, by frequently launching inflammatory responses towards pathogen infection and inner danger signal outbreak.
Acute and chronic inflammatory responses are critical determinants for consequences of kidney diseases, in which inflammasomes were inevitably involved.
Inflammasomes are closely linked to many kidney diseases such as acute kidney injury and chronic kidney diseases.
Inflammasomes are macromolecules consisting of multiple proteins, and their formation initiates the cleavage of procaspase-1, resulting in the activation of gasdermin D as well as the maturation and release of interleukin-1β and IL-18, leading to pyroptosis.
Here, we discuss the mechanism in which inflammasomes occur, as well as their roles in inflammatory kidney diseases, in order to shed light for discovering new therapeutical targets for the prevention and treatment of inflammatory kidney diseases and consequent end-stage renal disease.
American Psychological Association (APA)
Fan, Jinjin& Xie, Kaifeng& Wang, Liqin& Zheng, Nuoyan& Yu, Xueqing. 2019. Roles of Inflammasomes in Inflammatory Kidney Diseases. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192746
Modern Language Association (MLA)
Fan, Jinjin…[et al.]. Roles of Inflammasomes in Inflammatory Kidney Diseases. Mediators of Inflammation No. 2019 (2019), pp.1-14.
https://search.emarefa.net/detail/BIM-1192746
American Medical Association (AMA)
Fan, Jinjin& Xie, Kaifeng& Wang, Liqin& Zheng, Nuoyan& Yu, Xueqing. Roles of Inflammasomes in Inflammatory Kidney Diseases. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-14.
https://search.emarefa.net/detail/BIM-1192746
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192746