Interleukin-12p35 Deficiency Reverses the Th1Th2 Imbalance, Aggravates the Th17Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-- Mice
Joint Authors
Chang, Chao
Liu, Ling
Que, Bin
Wang, Zhen
Ye, Jing
Huang, Ying
Shi, Lei
Zeng, Tao
Shi, Ying
Hu, Haiying
Liu, Wenjing
Lin, Ying-zhong
Ji, Qing-wei
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Interleukin- (IL-) 35, a novel functional cytokine of regulatory T cells (Treg) comprised of the IL-12p35 subunit and the other subunit Epstein-Barr virus-induced gene 3 (EBI3), regulates the activity of CD4+ T cells and macrophages, thereby playing a critical role in inflammatory and autoimmune diseases.
Previous studies demonstrated that both recombinant mice and human IL-35 attenuated atherosclerosis in ApoE-/- mice.
Additionally, EBI3 deficiency enhanced the activation of macrophages and increased atherosclerotic lesions in LDLR-/- mice.
This study generated double-deficient mice for ApoE and IL-12p35 (ApoE-/- IL-12p35-/- mice) and investigated the effect of IL-12p35 deficiency on atherosclerosis.
IL-12p35 deficiency alleviated Th1/Th2 imbalance, aggravated Th17/Treg imbalance, and attenuated atherosclerotic plaque formation in ApoE-/- mice.
Additionally, exogenous rIL-35 treatment reversed the imbalance of Th17/Treg and attenuated atherosclerosis in ApoE-/- mice.
These findings suggest that IL-12p35 deficiency ameliorates atherosclerosis in ApoE-/- mice, partially, via attenuating the Th1/Th2 imbalance, although IL-12p35 deficiency aggravates the Th17/Treg imbalance.
American Psychological Association (APA)
Huang, Ying& Hu, Haiying& Liu, Ling& Ye, Jing& Wang, Zhen& Que, Bin…[et al.]. 2019. Interleukin-12p35 Deficiency Reverses the Th1Th2 Imbalance, Aggravates the Th17Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-- Mice. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192771
Modern Language Association (MLA)
Huang, Ying…[et al.]. Interleukin-12p35 Deficiency Reverses the Th1Th2 Imbalance, Aggravates the Th17Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-- Mice. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1192771
American Medical Association (AMA)
Huang, Ying& Hu, Haiying& Liu, Ling& Ye, Jing& Wang, Zhen& Que, Bin…[et al.]. Interleukin-12p35 Deficiency Reverses the Th1Th2 Imbalance, Aggravates the Th17Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-- Mice. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192771
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192771
