Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation
Joint Authors
Johnson, Richard J.
Lanaspa, Miguel A.
Shah, Jigesh A.
Tanabe, Tatsu
Watanabe, Hironosuke
Yamada, Kazuhiko
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Considerable shortages in the supply of available organs continue to plague the field of solid organ transplantation.
Despite changes in allocation, as well as the utilization of extended criteria and living donors, the number of patients waiting for organs continues to grow at an alarming pace.
Xenotransplantation, cross-species solid organ transplantation, offers one potential solution to this dilemma.
Previous extensive research dedicated to this field has allowed for resolution of xenograft failure due to acute rejection, leaving new areas of unresolved challenges as barriers to success in large animal models.
Specific to kidney xenotransplantation, recent data seems to indicate that graft compromise can occur due to discrepancies in growth between breeds of donors and significant proteinuria leading to nephrotic syndrome in the recipient.
Given these potential limitations, herein, we review potential pathways behind proteinuria, as well as potential causative factors related to growth discrepancies.
Control of both of these has the potential to allow xenotransplantation to become clinically applicable in an effort to resolve this organ shortage crisis.
American Psychological Association (APA)
Shah, Jigesh A.& Lanaspa, Miguel A.& Tanabe, Tatsu& Watanabe, Hironosuke& Johnson, Richard J.& Yamada, Kazuhiko. 2018. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192776
Modern Language Association (MLA)
Shah, Jigesh A.…[et al.]. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. Journal of Immunology Research No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1192776
American Medical Association (AMA)
Shah, Jigesh A.& Lanaspa, Miguel A.& Tanabe, Tatsu& Watanabe, Hironosuke& Johnson, Richard J.& Yamada, Kazuhiko. Remaining Physiological Barriers in Porcine Kidney Xenotransplantation: Potential Pathways behind Proteinuria as well as Factors Related to Growth Discrepancies following Pig-to-Kidney Xenotransplantation. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1192776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192776