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An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity
Joint Authors
Chen, Chun-Bing
Abe, Riichiro
Pan, Ren-You
Wang, Chuang-Wei
Tsai, Yi-Giien
Chung, Wen-Hung
Hung, Shuen-Iu
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-13
Country of Publication
Egypt
No. of Pages
22
Main Subjects
Abstract EN
Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS), or Stevens–Johnson syndrome (SJS)/toxic epidermal necrolysis (TEN).
Current pharmacogenomic studies have made important strides in the prevention of some drug hypersensitivity through the identification of relevant genetic variants, particularly for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs).
The associations identified by these studies are usually drug, phenotype, and ethnic specific.
The drug presentation models that explain how small drug antigens might interact with HLA and T cell receptor (TCR) molecules in drug hypersensitivity include the hapten theory, the p-i concept, the altered peptide repertoire model, and the altered TCR repertoire model.
The broad spectrum of clinical manifestations of drug hypersensitivity involving different drugs, as well as the various pathomechanisms involved, makes the diagnosis and management of it more challenging.
This review highlights recent advances in our understanding of the predisposing factors, immune mechanisms, pathogenesis, diagnostic tools, and therapeutic approaches for drug hypersensitivity.
American Psychological Association (APA)
Chen, Chun-Bing& Abe, Riichiro& Pan, Ren-You& Wang, Chuang-Wei& Hung, Shuen-Iu& Tsai, Yi-Giien…[et al.]. 2018. An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1192778
Modern Language Association (MLA)
Chen, Chun-Bing…[et al.]. An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity. Journal of Immunology Research No. 2018 (2018), pp.1-22.
https://search.emarefa.net/detail/BIM-1192778
American Medical Association (AMA)
Chen, Chun-Bing& Abe, Riichiro& Pan, Ren-You& Wang, Chuang-Wei& Hung, Shuen-Iu& Tsai, Yi-Giien…[et al.]. An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1192778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192778