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The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis
Joint Authors
Wong, Won Fen
Tan, Chong Tin
Abdullah, S.
Source
Multiple Sclerosis International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
There have been inconsistent reports on the prevalence and pathogenicity of anti-Aquaporin 4 (AQP4) in patients presented with idiopathic inflammatory demyelinating diseases (IIDDs).
Objective.
To estimate the prevalence of anti-AQP4 antibody in patients with IIDDs presented to University Malaya Medical Centre in terms of patients’ clinical and radiological presentations and prognoses.
Methods.
Retrospective data review of IIDDs patients presented from 2005 to 2015.
Patients were classified into classical multiple sclerosis (CMS), opticospinal (OS) presentation, optic neuritis (ON), transverse myelitis (TM), brainstem syndrome (BS), and tumefactive MS.
Anti-Aquaporin 4 antibody was tested using the Indirect Immunofluorescence Test (IIFT) cell-based assay.
Statistical analysis was done using the SPSS version 20.
Results.
Anti-AQP4 antibody was detected in 53% of patients presented with IIDDs.
CMS was more common in the seronegative group, 27/47 (57.45%; p<0.001).
Conversely, OS involvement was more common in the seropositive group, 26/53 (49.06%; p<0.001).
Longitudinally extensive spinal cord lesions (LESCLs) on MRI were also more common in the seropositive group, 29/40 (72.50%; p=0.004).
Only 2/40 (5.00%) had MRI evidence of patchy or multiple short-segment spinal cord lesions in the AQP4-positive group (p=0.003).
The relapse rate and Expanded Disability Status Scale (EDSS) were also higher in the seropositive group (5.43 versus 3.17, p=0.005; 4.07 versus 2.51, p=0.006, resp.).
Typical clinical presentations that defined NMO were also seen in the seronegative patients, but in a lower frequency.
Conclusion.
Our cohort of patients had a higher prevalence of seropositivity of anti-AQP4 antibody as compared to those in Western countries.
This was also associated with a more typical presentation of opticospinal involvement with LESCLs on MRI, a higher rate of relapse, and EDSS.
American Psychological Association (APA)
Abdullah, S.& Wong, Won Fen& Tan, Chong Tin. 2017. The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis. Multiple Sclerosis International،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1192838
Modern Language Association (MLA)
Abdullah, S.…[et al.]. The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis. Multiple Sclerosis International No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1192838
American Medical Association (AMA)
Abdullah, S.& Wong, Won Fen& Tan, Chong Tin. The Prevalence of Anti-Aquaporin 4 Antibody in Patients with Idiopathic Inflammatory Demyelinating Diseases Presented to a Tertiary Hospital in Malaysia: Presentation and Prognosis. Multiple Sclerosis International. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1192838
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192838