The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients
Joint Authors
Biolik, Grzegorz
Gajniak, Dariusz
Kubicz, Maciej
Ziaja, Krzysztof
Kuczmik, Waclaw
Ziaja, Damian
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-07-17
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Knowledge about the influence of inflammation on platelet function and relocation of hemostatic balance to hypercoagulable state is still unclear.
We compared two groups of patients who suffer from acute vs.
chronic inflammatory process and additionally present high on-treatment platelet reactivity-dual platelet resistance.
We did not found any differences in platelet aggregation between both investigated groups, but patients who suffer from chronic inflammation presented stronger relocation of the hemostatic balance to the hypercoagulability.
A high concentration of prothrombin fragment F1+2 together with higher activity of von Willebrand factor in critical limb ischemia shows more exaggerated fibrinogen turnover although the blood concentration of this factor was in normal range.
We concluded that high on-treatment platelet reactivity-dual platelet resistance and intensified inflammation are linked with elevated platelet and fibrinogen turnover to counteract proper hemostatic balance in favor of a prothrombotic state.
American Psychological Association (APA)
Biolik, Grzegorz& Gajniak, Dariusz& Kubicz, Maciej& Ziaja, Damian& Ziaja, Krzysztof& Kuczmik, Waclaw. 2019. The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1192840
Modern Language Association (MLA)
Biolik, Grzegorz…[et al.]. The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients. Mediators of Inflammation No. 2019 (2019), pp.1-6.
https://search.emarefa.net/detail/BIM-1192840
American Medical Association (AMA)
Biolik, Grzegorz& Gajniak, Dariusz& Kubicz, Maciej& Ziaja, Damian& Ziaja, Krzysztof& Kuczmik, Waclaw. The Influence of Inflammation on Fibrinogen Turnover and Redistribution of the Hemostatic Balance to a Prothrombotic State in High On-Treatment Platelet Reactivity-Dual Poor Responder (HTPR-DPR) Patients. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-6.
https://search.emarefa.net/detail/BIM-1192840
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192840