The Effects of Aerobic Exercise on the Recovery of Walking Ability and Neuroplasticity in People with Multiple Sclerosis: A Systematic Review of Animal and Clinical Studies
Joint Authors
Ploughman, Michelle
Devasahayam, Augustine Joshua
Downer, Matthew Bruce
Source
Multiple Sclerosis International
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-17
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Introduction.
Walking is of high priority for people with multiple sclerosis (PwMS).
It remains unclear whether aerobic exercise can improve walking ability and upregulate neurotrophins.
This review aims to consolidate evidence to develop optimal aerobic training parameters to enhance walking outcomes and neuroplasticity in PwMS.
Methods.
Clinical studies examining aerobic exercise for ≥3 weeks, having outcomes on walking with or without neurotrophic markers, were included.
Studies utilizing animal models of MS were included if they employed aerobic exercise with outcomes on neurological recovery and neurotrophins.
From a total of 1783 articles, 12 clinical and 5 animal studies were included.
Results.
Eleven clinical studies reported improvements in walking ability.
Only two clinical studies evaluated both walking and neurotrophins, and neither found an increase in neurotrophins despite improvements in walking.
Patients with significant walking impairments were underrepresented.
Long-term follow-up revealed mixed results.
Two animal studies reported a positive change in both neurological recovery and neurotrophins.
Conclusion.
Aerobic exercise improves walking ability in PwMS.
Gains are not consistently maintained at 2- to 9-month follow-up.
Studies examining levels of neurotrophins are inconclusive, necessitating further research.
Aerobic exercise enhances both neurological recovery and neurotrophins in animal studies when started 2 weeks before induction of MS.
American Psychological Association (APA)
Devasahayam, Augustine Joshua& Downer, Matthew Bruce& Ploughman, Michelle. 2017. The Effects of Aerobic Exercise on the Recovery of Walking Ability and Neuroplasticity in People with Multiple Sclerosis: A Systematic Review of Animal and Clinical Studies. Multiple Sclerosis International،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192843
Modern Language Association (MLA)
Devasahayam, Augustine Joshua…[et al.]. The Effects of Aerobic Exercise on the Recovery of Walking Ability and Neuroplasticity in People with Multiple Sclerosis: A Systematic Review of Animal and Clinical Studies. Multiple Sclerosis International No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1192843
American Medical Association (AMA)
Devasahayam, Augustine Joshua& Downer, Matthew Bruce& Ploughman, Michelle. The Effects of Aerobic Exercise on the Recovery of Walking Ability and Neuroplasticity in People with Multiple Sclerosis: A Systematic Review of Animal and Clinical Studies. Multiple Sclerosis International. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1192843
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192843