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The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study
Joint Authors
Visentainer, Jeane Eliete Laguila
Zacarias, Joana Maira Valentini
Tsuneto, Patrícia Yumeko
Sell, Ana M.
de Souza, Victor Hugo
de Alencar, Josiane Bazzo
Silva, C.
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-06-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The pathogenesis of periodontitis involves a complex interaction between the microbial challenge and the host immune response.
The individual immunoinflammatory response has a great contribution in the pathogenesis of the disease and becomes a trigger in the process of bone remodeling which is a characteristic of the disease.
Thus, the aim of this study was to evaluate the influence of the TLR4 A896G (rs4986790), TLR4 C1196T (rs4986791), CD14 C-260T (rs2569190), RANKL (TNFSF11, rs2277438), and OPG (TNFSF11B C163T, rs3102735) polymorphisms in periodontitis.
A case-control study was conducted on patients with periodontitis (N=203) and controls (N=213) over 30 years of age, without diabetes mellitus, acute infections, and osteoarthritis, and patients without aggressive periodontitis, i.e., stage IV and C degree of periodontitis, and any periodontal treatment performed in the last 6 months.
Genotypes were determined by the PCR-RFLP and sequencing method.
The frequency comparisons between case and controls were performed using the chi-square test and logistic regression (OpenEpi and SNPStats software).
The risk (OR) was evaluated for values of P<0.05.
Differences in TLR4, CD14, RANKL, and OPG genotype and allele frequency distributions were not observed between patients and controls.
However, some variants were a risk factor for the development of periodontitis when considering gender and smoking habits.
The TLR4 896 A/G genotype was a risk factor for periodontitis in males (OR=2.86), and the TLR4 1196C/C genotype was a risk factor for nonsmoking males (OR=1.85) when compared to women.
The RANKL A/A and the OPG T/C genotype was associated with the risk of the disease in nonsmoking men compared to nonsmoking women with the same genotype (OR=1.96 and OR=2.9, respectively).
In conclusion, TLR4, CD14, RANKL, and OPG variants were not associated with periodontitis.
However, TLR4, RANKL, and OPG polymorphisms could be a risk for periodontitis in males regardless of smoking habits.
American Psychological Association (APA)
Zacarias, Joana Maira Valentini& de Alencar, Josiane Bazzo& Tsuneto, Patrícia Yumeko& de Souza, Victor Hugo& Silva, C.& Visentainer, Jeane Eliete Laguila…[et al.]. 2019. The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192844
Modern Language Association (MLA)
Zacarias, Joana Maira Valentini…[et al.]. The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study. Mediators of Inflammation No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1192844
American Medical Association (AMA)
Zacarias, Joana Maira Valentini& de Alencar, Josiane Bazzo& Tsuneto, Patrícia Yumeko& de Souza, Victor Hugo& Silva, C.& Visentainer, Jeane Eliete Laguila…[et al.]. The Influence of TLR4, CD14, OPG, and RANKL Polymorphisms in Periodontitis: A Case-Control Study. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1192844
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192844