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Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women
Joint Authors
Tinahones, Francisco J.
Gomez-Huelgas, Ricardo
Ruiz-Nava, Josefina
Santamaria-Fernandez, Sonia
Vargas-Candela, Antonio
Alarcon-Martin, Ana Victoria
Bernal-Lopez, M. Rosa
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-04-09
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
For the metabolically healthy obese (MHO) subjects, it is unclear whether weight loss provides cardiometabolic benefits.
Our objective was to evaluate whether changes in adipokine and inflammatory biomarker levels were related to lifestyle modification (with Mediterranean diet and physical exercise program).
Methods.
115 women (35-55 years) with BMI of 30-40 kg/m2 and ≤1 metabolic syndrome criteria were included.
After a 2-year intervention, participants were classified by percent weight loss: Group 1, <5%; Group 2, ≥5%-<10%; and Group 3, ≥10%.
Anthropometric data, inflammatory biomarker (IL-6, TNFa, and hsCRP) and adipokine levels (adiponectin and resistin), and lifestyle program adherence at baseline and 2 years were analyzed.
Results.
The final sample comprised 67 women.
23 (38.3%) lost <5%, 22 (36.7%) lost ≥5%-<10%, and 22 (36.7%) lost ≥10% of baseline weight.
After 2 years, in Group 1, adiponectin, hsCRP, IL-6, and TNFa decreased (-1.2 ng/ml, p=0.003; -2.1 mg/l, p=0.003; -2.4 pg/ml, p<0.001; and -2.4 pg/ml, p=0.001, respectively) and resistin increased (+2.4 ng/ml, p<0.001).
In Group 2, hsCRP and IL-6 decreased (-2.0 mg/l, p=0.009 and -2.6 pg/ml, p=0.001) but TNFa increased (+0.2 pg/ml, p=0.02).
In Group 3, resistin increased (+3.5 ng/ml, p<0.001) but hsCRP, IL-6, and TNFa decreased (-2.0 mg/l, p=0.009; -2.5 pg/ml, p<0.001; and -4.1 pg/ml, p<0.001).
Adiponectin, hsCRP, and physical exercise correlated significantly to subjects’ dietary adherence.
Conclusion.
Weight loss reduces inflammatory biomarkers in the MHO but induces a deterioration in the adipokine profile, which does not improve with diet and exercise intervention.
These findings allow us to clarify mechanisms behind inflammation and metabolic disorder genesis so as to prevent development of obesity-associated comorbidities.
American Psychological Association (APA)
Gomez-Huelgas, Ricardo& Ruiz-Nava, Josefina& Santamaria-Fernandez, Sonia& Vargas-Candela, Antonio& Alarcon-Martin, Ana Victoria& Tinahones, Francisco J.…[et al.]. 2019. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192857
Modern Language Association (MLA)
Gomez-Huelgas, Ricardo…[et al.]. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators of Inflammation No. 2019 (2019), pp.1-9.
https://search.emarefa.net/detail/BIM-1192857
American Medical Association (AMA)
Gomez-Huelgas, Ricardo& Ruiz-Nava, Josefina& Santamaria-Fernandez, Sonia& Vargas-Candela, Antonio& Alarcon-Martin, Ana Victoria& Tinahones, Francisco J.…[et al.]. Impact of Intensive Lifestyle Modification on Levels of Adipokines and Inflammatory Biomarkers in Metabolically Healthy Obese Women. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-9.
https://search.emarefa.net/detail/BIM-1192857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192857