Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6

Joint Authors

Zheng, Yijun
Zhao, Quan-ming
Yi, Lei
Zhou, Zengding
Chang, Mengling
Huang, Xiaoqin
Guo, Feng
Huan, Jingning

Source

Mediators of Inflammation

Issue

Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2019-12-30

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Diseases

Abstract EN

Background.

Under septic conditions, LPS induced lung vascular endothelial cell (EC) injury, and the release of inflammatory mediator launches and aggravates acute lung injury (ALI).

There are no effective therapeutic options for ALI.

Genistein-3′-sodium sulfonate (GSS) is a derivative of native soy isoflavone, which exhibits neuroprotective effects via its antiapoptosis property.

However, whether GSS protect against sepsis-induced EC injury and release of inflammatory mediators has not been determined.

In this study, we found that GSS not only downregulated the levels of TNF-α and IL-6 in the lung and serum of mice in vivo but also inhibited the expression and secretion of TNF-α and IL-6 in ECs.

Importantly, we also found that GSS blocked LPS-induced TNF-α and IL-6 expression in ECs via the Myd88/NF-κB signaling pathway.

Taken together, our results demonstrated that GSS might be a promising candidate for sepsis-induced ALI via its regulating effects on inflammatory response in lung ECs.

American Psychological Association (APA)

Yi, Lei& Zhou, Zengding& Zheng, Yijun& Chang, Mengling& Huang, Xiaoqin& Guo, Feng…[et al.]. 2019. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192861

Modern Language Association (MLA)

Yi, Lei…[et al.]. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192861

American Medical Association (AMA)

Yi, Lei& Zhou, Zengding& Zheng, Yijun& Chang, Mengling& Huang, Xiaoqin& Guo, Feng…[et al.]. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192861

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1192861