Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6
Joint Authors
Zheng, Yijun
Zhao, Quan-ming
Yi, Lei
Zhou, Zengding
Chang, Mengling
Huang, Xiaoqin
Guo, Feng
Huan, Jingning
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-12-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Under septic conditions, LPS induced lung vascular endothelial cell (EC) injury, and the release of inflammatory mediator launches and aggravates acute lung injury (ALI).
There are no effective therapeutic options for ALI.
Genistein-3′-sodium sulfonate (GSS) is a derivative of native soy isoflavone, which exhibits neuroprotective effects via its antiapoptosis property.
However, whether GSS protect against sepsis-induced EC injury and release of inflammatory mediators has not been determined.
In this study, we found that GSS not only downregulated the levels of TNF-α and IL-6 in the lung and serum of mice in vivo but also inhibited the expression and secretion of TNF-α and IL-6 in ECs.
Importantly, we also found that GSS blocked LPS-induced TNF-α and IL-6 expression in ECs via the Myd88/NF-κB signaling pathway.
Taken together, our results demonstrated that GSS might be a promising candidate for sepsis-induced ALI via its regulating effects on inflammatory response in lung ECs.
American Psychological Association (APA)
Yi, Lei& Zhou, Zengding& Zheng, Yijun& Chang, Mengling& Huang, Xiaoqin& Guo, Feng…[et al.]. 2019. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192861
Modern Language Association (MLA)
Yi, Lei…[et al.]. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1192861
American Medical Association (AMA)
Yi, Lei& Zhou, Zengding& Zheng, Yijun& Chang, Mengling& Huang, Xiaoqin& Guo, Feng…[et al.]. Suppressive Effects of GSS on Lipopolysaccharide-Induced Endothelial Cell Injury and ALI via TNF-α and IL-6. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1192861
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192861