miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation
Joint Authors
Ye, Jinshan
Guo, Ruiwei
Yang, Lixia
Wu, Yaxi
Zeng, Wenjun
Duan, Yanan
Yang, Zhihua
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-09-03
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Atherosclerosis (AS) is a chronic inflammatory disease, and macrophages play a key role in all phases of AS.
Recent studies have shown that miR-221 is a biomarker for AS and stroke; however, the role and mechanism of miR-221 in AS are unclear.
Herein, we found that miR-221 and NCoR levels were decreased in ox-LDL-treated THP-1-derived macrophages.
In contrast, DNMT3b, IL-6, and TNF-α expression levels were increased under these conditions.
Upregulation of miR-221 or NCoR could partially inhibit ox-LDL-induced IL-6 and TNF-α expression.
Further studies showed that DNMT3b was a target of miR-221.
DNMT3b inhibition also suppressed IL-6 and TNF-α expression and increased NCoR expression in the presence of ox-LDL.
Moreover, DNMT3b was involved in ox-LDL-induced DNA methylation in the promoter region of NCoR.
These findings suggest that miR-221 suppresses ox-LDL-induced inflammatory responses via suppressing DNMT3b-mediated DNA methylation in the promoter region of NCoR.
These results provide a rationale for using intracellular miR-211 as a possible antiatherosclerotic target.
American Psychological Association (APA)
Ye, Jinshan& Wu, Yaxi& Guo, Ruiwei& Zeng, Wenjun& Duan, Yanan& Yang, Zhihua…[et al.]. 2019. miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192866
Modern Language Association (MLA)
Ye, Jinshan…[et al.]. miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation. Mediators of Inflammation No. 2019 (2019), pp.1-15.
https://search.emarefa.net/detail/BIM-1192866
American Medical Association (AMA)
Ye, Jinshan& Wu, Yaxi& Guo, Ruiwei& Zeng, Wenjun& Duan, Yanan& Yang, Zhihua…[et al.]. miR-221 Alleviates the Ox-LDL-Induced Macrophage Inflammatory Response via the Inhibition of DNMT3b-Mediated NCoR Promoter Methylation. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-15.
https://search.emarefa.net/detail/BIM-1192866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192866