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The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection
Joint Authors
Yang, Xi
Zhao, Lei
Gao, Xiaoling
Bai, Hong
Joyee, Antony George
Wang, Shuhe
Yang, Jie
Zhao, Weiming
Source
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-05-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Chlamydia pneumoniae (Cpn) infection causes multiple acute and chronic human diseases.
The role of DCs in host defense against Cpn infection has been well documented.
The same is true for invariant natural killer T (iNKT) cells and NK cells, but the interaction among cells is largely unknown.
In this study, we investigated the influence and mechanism of iNKT cell on the differentiation and function of NK cell in Cpn lung infection and the role played by DCs in this process.
We found that expansion of IFN-γ-producing NK cells quickly happened after the infection, but this response was altered in iNKT knockout (KO) mice.
The expression of activation markers and the production of IFN-γ by different NK subsets were significantly lower in KO mice than wild-type (WT) mice.
Using in vitro DC-NK coculture and in vivo adoptive transfer approaches, we further examined the role of DCs in iNKT-mediated modulation of NK cell function.
We found that NK cells expressed lower levels of activation markers and produced less IFN-γ when they were cocultured with DCs from KO mice than WT mice.
More importantly, we found that the adoptive transfer of DCs from the KO mice induced less NK cell activation and IFN-γ production.
The results provided evidence on the modulating effect of iNKT cell on NK cell function, particularly the critical role of DCs in this modulation process.
The finding suggests the complexity of cellular interactions in Cpn lung infection, which should be considered in designing preventive and therapeutic approaches for diseases and infections.
American Psychological Association (APA)
Zhao, Lei& Gao, Xiaoling& Bai, Hong& Joyee, Antony George& Wang, Shuhe& Yang, Jie…[et al.]. 2019. The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection. Mediators of Inflammation،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192883
Modern Language Association (MLA)
Zhao, Lei…[et al.]. The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection. Mediators of Inflammation No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1192883
American Medical Association (AMA)
Zhao, Lei& Gao, Xiaoling& Bai, Hong& Joyee, Antony George& Wang, Shuhe& Yang, Jie…[et al.]. The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection. Mediators of Inflammation. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1192883
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192883