Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response
Joint Authors
Wang, Ling-Cong
Ying, Song-Min
Feng, Wen
Shi, Ying
Zhang, Zhirong
Cai, Danli
Kuang, Jing
Jin, Shuifang
Zhu, Chen
Shen, Yingying
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-25
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Inflammatory response is an important determining factor for the mortality of patients with pulmonary thromboembolism.
Inflammatory mediators can promote thrombus formation and increase hemodynamic instability.
Urokinase is a commonly used drug for the treatment of PTE.
The effect of urokinase on inflammatory reaction in PTE is still unclear.
Our study was aimed at evaluating the effects of the intervention of urokinase and urokinase combined with aspirin in PTE rats.
Results revealed that a large amount of infiltrated inflammatory cells surrounding the bronchus, vessels, and pulmonary mesenchyme, and even pulmonary abscess were observed in the PTE rats.
CX3CL1/CX3CR1 coexpression, CX3CL1/NF-κB coexpression, and TXA2 were significantly higher.
After treatment with urokinase, pulmonary embolism was partially dissolved and inflammatory cell infiltration was significantly reduced.
The expression of TNNI3, BNP, D2D, PASP, PADP, PAMP, and TXA2, as well as CX3CL1/CX3CR1 coexpression and CX3CL1/NF-κB coexpression were significantly lowered.
Aspirin showed no synergistic action.
Therefore, these findings suggested the occurrence of inflammation during the process of PTE in rats.
Urokinase treatment reduced the inflammatory response.
American Psychological Association (APA)
Shi, Ying& Zhang, Zhirong& Cai, Danli& Kuang, Jing& Jin, Shuifang& Zhu, Chen…[et al.]. 2018. Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192895
Modern Language Association (MLA)
Shi, Ying…[et al.]. Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1192895
American Medical Association (AMA)
Shi, Ying& Zhang, Zhirong& Cai, Danli& Kuang, Jing& Jin, Shuifang& Zhu, Chen…[et al.]. Urokinase Attenuates Pulmonary Thromboembolism in an Animal Model by Inhibition of Inflammatory Response. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192895
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192895