Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress
Joint Authors
Carvalho, Clarissa Gutiérrez
Procianoy, Renato Soibelmann
Neto, Eurico Camargo
Silveira, Rita C.
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Ventilator-induced lung injury is well recognized, and appropriate arterial saturation target is unknown, so gentle modes of ventilation and minimizing oxidative stress have been well studied.
Our objective was to analyze any association between the oxygen levels at blood sampling and plasma levels of the interleukins IL-6, IL-1β, IL-10, and IL-8 and TNF-α in preterm newborns under mechanical ventilation (MV) in their first two days.
Methods.
Prospective cohort including neonates with severe respiratory distress.
Blood samples were collected right before and 2 hours after invasive MV.
For analysis purposes, newborns were separated according to oxygen requirement: low oxygen (≤30%) and high oxygen (>30%) groups.
Interleukins were measured using a commercially available kit.
Results.
20 neonates (gestational age 32.2 ± 3 weeks) were evaluated.
Median O2 saturation levels pre-MV were not different in both oxygen groups.
In the high oxygen group, IL-6, IL-8, and TNF-α plasma levels increased significantly after two hours under MV.
Conclusions.
Despite the small sample studied, data showed that there is a relationship between VILI, proinflammatory cytokines, and oxygen-induced lung injury, but a study considering oxidative marker measurements is needed.
It seems that less oxygen may keep safer saturation targets playing a less harmful role.
American Psychological Association (APA)
Carvalho, Clarissa Gutiérrez& Procianoy, Renato Soibelmann& Neto, Eurico Camargo& Silveira, Rita C.. 2018. Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1192903
Modern Language Association (MLA)
Carvalho, Clarissa Gutiérrez…[et al.]. Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress. Journal of Immunology Research No. 2018 (2018), pp.1-4.
https://search.emarefa.net/detail/BIM-1192903
American Medical Association (AMA)
Carvalho, Clarissa Gutiérrez& Procianoy, Renato Soibelmann& Neto, Eurico Camargo& Silveira, Rita C.. Preterm Neonates with Respiratory Distress Syndrome: Ventilator-Induced Lung Injury and Oxidative Stress. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-4.
https://search.emarefa.net/detail/BIM-1192903
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192903