STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer
Joint Authors
Weixing, Wang
Ma, Hulin
Gao, Weishi
Sun, Xiaoxia
Source
Journal of Immunology Research
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The tumor-infiltrating Tregs are linked to colorectal cancer progression and outcome.
FOXP3 is regarded as a critical developmental and functional factor for Tregs.
FOXP3-TSDR demethylation is required for stable expression of FOXP3 and maintenance of Treg function.
In our study, we found specific DNA hypomethylation of FOXP3-TSDR in CD4+ T cells from colon tumor tissues as compared with normal colonic tissues.
Moreover, we also found that the expression of STAT5 and TET2 was increased in CD4+ T cells from colon tumor tissues, and the superfluous STAT5 and TET2 binding to FOXP3-TSDR resulted in DNA hypomethylation.
In conclusion, we have demonstrated that excessive amounts of STAT5 may bind more TET2 to the FOXP3-TSDR and upregulate FOXP3 expression via DNA demethylation.
Our study improved the mechanism of FOXP3-TSDR hypomethylation in tumor-infiltrating CD4+ T cells of CRC patients.
American Psychological Association (APA)
Ma, Hulin& Gao, Weishi& Sun, Xiaoxia& Weixing, Wang. 2018. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Journal of Immunology Research،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192908
Modern Language Association (MLA)
Ma, Hulin…[et al.]. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Journal of Immunology Research No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1192908
American Medical Association (AMA)
Ma, Hulin& Gao, Weishi& Sun, Xiaoxia& Weixing, Wang. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Journal of Immunology Research. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1192908
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192908