Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury
Joint Authors
Leem, Joong Woo
Gwak, Young S.
Hulsebosch, Claire E.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-29
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
The hyperactive state of sensory neurons in the spinal cord enhances pain transmission.
Spinal glial cells have also been implicated in enhanced excitability of spinal dorsal horn neurons, resulting in pain amplification and distortions.
Traumatic injuries of the neural system such as spinal cord injury (SCI) induce neuronal hyperactivity and glial activation, causing maladaptive synaptic plasticity in the spinal cord.
Recent studies demonstrate that SCI causes persistent glial activation with concomitant neuronal hyperactivity, thus providing the substrate for central neuropathic pain.
Hyperactive sensory neurons and activated glial cells increase intracellular and extracellular glutamate, neuropeptides, adenosine triphosphates, proinflammatory cytokines, and reactive oxygen species concentrations, all of which enhance pain transmission.
In addition, hyperactive sensory neurons and glial cells overexpress receptors and ion channels that maintain this enhanced pain transmission.
Therefore, post-SCI neuronal-glial interactions create maladaptive synaptic circuits and activate intracellular signaling events that permanently contribute to enhanced neuropathic pain.
In this review, we describe how hyperactivity of sensory neurons contributes to the maintenance of chronic neuropathic pain via neuronal-glial interactions following SCI.
American Psychological Association (APA)
Gwak, Young S.& Hulsebosch, Claire E.& Leem, Joong Woo. 2017. Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury. Neural Plasticity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1192911
Modern Language Association (MLA)
Gwak, Young S.…[et al.]. Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury. Neural Plasticity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1192911
American Medical Association (AMA)
Gwak, Young S.& Hulsebosch, Claire E.& Leem, Joong Woo. Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury. Neural Plasticity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1192911
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1192911